张小昕,讲师,生化教研室,邮箱:zhangxiaoxin2014@163.com
【学习工作经历】
2010.9-2014.6江苏海洋大学(原淮海工学院),生物技术,本科
2014.9-2019.6上海交通大学医学院,生物化学与分子生物学,博士
2019.7-2020.4艾昆纬企业管理咨询(上海)有限公司,管理咨询部,助理咨询顾问
2020.5-至今江苏大学医学院,讲师
【教改科研项目】
1.国家自然科学基金青年项目,8210115358,外泌体GPAA1介导胃癌细胞与肝星状细胞交互作用促进转移前微环境形成的机制研究,主持,2022.1-2024.12
2.江苏省高校自然科学基金面上项目,21KJB320013,肿瘤相关成纤维细胞介导的Netrin-1-UNC5C轴促进胰腺癌进展的机制,主持,2021.10-2023.9
【人才项目及荣誉称号】
2021年入选江苏省“双创博士”
【代表性论文】(#第一作者,*通讯作者)
1.Xiao-Xin Zhang#; Bo Ni#; Qing Li#; Li-Peng Hu#; Shu-Heng Jiang; Chun-Chao Zhu*; Zhi-Gang Zhang*; GPAA1 promotes gastric cancer progression via upregulation of GPI-anchored protein and enhancement of ERBB signalling pathway, Journal of Experimental & Clinical Cancer Research, 2019, 38(1): 214-214.
2.Li-Peng Hu#; Xiao-Xin Zhang#; Shu-Heng Jiang#; Yong-Wei Sun*; Zhi-Gang Zhang*; Targeting Purinergic Receptor P2Y2 prevents the growth of pancreatic ductal adenocarcinoma by inhibiting cancer cell glycolysis, Clinical Cancer Research, 2018, Feb 15;25(4): 1318-1330.
3.Shu-Heng Jiang#; Xiao-Xin Zhang#; Li-Peng Hu; Jian-Ren Gu*; Zhi-Gang Zhang*; Systemic Regulation of Cancer Development by Neuro-Endocrine-Immune Signaling Network at Multiple Levels, Frontiers in cell and developmental biology, 2020, 8:586757
4.Wang M, Gu J, Zhang X, Yang J, Zhang X*, Fang X*. Long Non-coding RNA DANCR in Cancer: Roles, Mechanisms, and Implications. Front Cell Dev Biol. 2021;9:753706. Published 2021 Oct 15. doi:10.3389/fcell.2021.753706
5.Xiao-Yan Cao#; Xiao-Xin Zhang#; Min-Wei Yang#;Yong-Wei Sun*; Zhi-Gang Zhang*; Aberrant upregulation of KLK10 promotes metastasis via enhancement of EMT and FAK/SRC/ERK axis in PDAC, Biochemical and Biophysical Research Communications,2018, 499(3): 593
【获奖与专利】
1.中国抗癌协会,中国肿瘤标志物学术大会TBM青年优秀论文奖
2.中国博士后科学基金会,全国新医药技术创新博士后学术论坛创新论文奖