张盈,副教授,硕士生导师,医学生物化学教研室,主要从事病原菌致病分子机制及细菌与宿主相互作用关系的研究。邮箱:zhangyingzj85@163.com
【学习工作经历】
2019.05-至今,江苏大学,医学院基础医学系,副教授
2018.08-至今,江苏大学,医学院基础医学系,博士后
2012.06-2019.05,江苏大学,医学院基础医学系,讲师
2007.09-2012.06,南京理工大学,博士
2003.09-2007.06,南京理工大学,学士
【教改科研项目】
1.江苏省博士后科研资助计划,2021K209B,VI型分泌系统通过SopE增加伤寒沙门菌在巨噬细胞内生存力的机制研究,2021.07-2022.06,在研,主持
2.江苏省高等学校自然科学研究重大项目,20KJA310006,伤寒沙门菌T6SS通过T3SS-1增加SCV稳定性的作用机制研究,2020.10-2023.09,在研,主持
3.中国博士后科学基金面上资助,2018M642186,T6SS在伤寒沙门菌与巨噬细胞相互作用中的功能研究,2019.01-2021.12,在研,主持
4.国家自然科学基金青年基金,31400125,malS-5'UTR调节伤寒沙门菌耐酸力和侵袭力的作用机制研究,2015.01-2017.12,已结题,主持
5.江苏省自然科学基金青年基金,BK20130504,伤寒沙门菌sRNA1068的作用及分子机制研究,2013.07-2016.06,已结题,主持
【代表性论文】
1.Zhao X, Yang F, Wang Y,Zhang Y*. hns mRNA downregulates the expression of galU and attenuates the motility of Salmonella enterica serovar Typhi. Int J Med Microbiol. 2021, 311: 151525.
2.Yang F, Sheng X, Huang X,Zhang Y*. Interactions between Salmonella and host macrophages - Dissecting NF-κB signaling pathway responses. Microb Pathog. 2021, 154: 104846.
3.Xie Z,Zhang Y*, Huang X*, Evidences and speculations: the response of Salmonella confronted by autophagy in macrophages.Future Microbiol, 2020, 15:1277-1286.
4.Zhang Y#, Chong X#, Xia L, Lu R, Osei-Adjei G, Zhang Y, Huang X*, OxyR positively and directly regulates Vi polysaccharide capsular antigen inSalmonella entericaserovar Typhi,Microb Pathog, 2018, 124: 191-197.
5.Zhang Y, Xia L, Lin L, Tang H, Osei-Adjei G, Xu S, Zhang Y*, Huang X*,Reciprocal Regulation of OmpR and Hfq and Their Regulatory Actions on the Vi Polysaccharide Capsular Antigen inSalmonella entericaSerovar Typhi,Curr Microbiol, 2018, 75(6): 773-778.
6.Dong F, Xia L, Lu R, Zhao X, Zhang Y,Zhang Y*, Huang X*. ThemalS-5'UTR weakens the ability ofSalmonella entericaserovar Typhi to survive in macrophages by increasing intracellular ATP levels.Microb Pathog, 2018, 115: 321-331.
7.Zhang Y, Yan D, Xia L, Zhao X, Osei-Adjei G, Xu S, Sheng X, Huang X*, ThemalS-5'UTR regulateshisG, a keygene in the histidine biosynthetic pathway inSalmonella entericaserovar Typhi,Can J Microbiol, 2017, 63(4): 287-295.
8.Zhang Q#,Zhang Y#, Zhang X#, Zhan L, Zhao X, Xu S, Sheng X, Huang X*, The novelcis-encoded antisense RNA AsrC positively regulates the expression ofrpoE-rseABCoperon and thus enhances the motility ofSalmonella entericaserovar Typhi,Front Microbiol, 2015, 6: 990.
9.Zhang Y, Xia L, Pang W, Wang T, Chen P, Zhu B, Zhang J*, A novel soluble β-1, 3-D-glucan Salecan reduces adiposity and improves glucose tolerance in high-fat diet-fed mice,Br J Nutr, 2013, 109: 254-262.
10.Zhang Y, Wang Z, Zhao Y, Zhao M, Wang S, Hua Z, Zhang J*, The plasma 5'-AMP acts as a potential upstream regulator of hyperglycemia in type 2 diabetic mice,Am J Physiol Endocrinol Metab, 2012, 302: E325-333.
【教材与专著】
1.生物化学与分子生物学,张一鸣主编,东南大学出版社,2018年8月第2版,参编。
2.生物毒素学,王景林主编,科学出版社,2021年6月,参编。