医学院 ENGLISH 江苏大学首页

当前位置 首页 >> 师资队伍 >> 博导教授 >> 正文

夏圣


个人简介:

医学博士,教授,博士生导师,美国康奈尔大学博士后。现任江苏大学医学院医学检验系副主任,免疫学与免疫检验学教研室主任,江苏省免疫学会理事,江苏省医学会微生物与免疫学会理事。在BloodJBCEndocrinologyCancer Immun & ImmunotherDiabetesJ Immunol、《中国免疫学杂志》、《临床检验杂志》等国内外期刊上发表研究论文,主编及参编教材、专著十余部,主持省精品课程一门。

主讲课程:

《医学免疫学》(本科)、《临床免疫检验学》(本科)、《医学免疫学技术》(硕士研究生)、《Immunology(MBBS留学生)、《免疫学进展》(博士研究生)、《Advance in Immunology(留学研究生)等。

主要科研方向:

免疫调节、免疫治疗、免疫检验。

联系方式

Email: xiasheng1519@163.com

江苏大学医学院; 江苏省镇江市学府路301号江苏大学医学楼, 邮编  212013

主要科研项目:

1. 新型NKT细胞亚群治疗晚期肿瘤的I/II期临床研究 BE2017696),江苏省社会发展重点研发项目(临床前沿技术),

2. 高脂肥胖对肠道区域树突状细胞的影响及相关机制研究 31570879),国家自然科学基金面上项目,

3. 肥胖通过调控肠道菌群影响调节性T细胞功能的研究  31428006),国家自然科学基金海外及港澳学者合作研究项目,

4. ω3 脂肪酸诱导免疫耐受、促造血干细胞分化机制及其应用研究(81172834),国家自然科学基金面上项目,

部分研究论文:

1.    Jin H, Yan C, Xiao T, Yan N, Xu J, Zhou L, Zhou X, Shao Q, Xia S*. High fish oil diet promotes liver inflammation and activates the complement system. Mol Med Rep. 2018;17(5):6852-6858

2.    Qiang Y, Xu J, Yan C, Jin H, Xiao T, Yan N, Zhou L, An H, Zhou X, Shao Q, Xia S*. Butyrate and retinoic acid imprint mucosal-like dendritic cell development synergistically from bone marrow cells. Cin Exp Immunol. 2017189(3):290-297.

3.    Liu X, Wang J, Wang H, Zhou C, Yu Q, Yin L, Wu W, Xia S, Shao Q  Cell penetrable mouse forkhead box P3 suppresses type 1 T helper cell mediated immunity in a murine model of delayed type hypersensitivity.  Exp Ther Med. 2017;13(2):421-428.

4.    Cheng L, Jin H, Qiang Y, Wu S, Yan C, Han M, Xiao T, Yan N, An H, Zhou X, Shao Q, Xia S*. High fat diet exacerbates dextran sulfate sodium induced colitis through disturbing mucosal dendritic cell homeostasis. Int Immunopharmacol. 2016, 40(5):1-10.

5. Xia S*, Li XP, Cheng L, Han MT, Zhang MM, Shao QX, Xu HX, Qi L. Fish Oil-Rich DietPromotes Hematopoiesis and Alters Hematopoietic Niche. Endocrinology.2015;156(8):2821-30.  

6. Chen D, Wang Y, Wang H, Wu Y, Xia S*, Zhang M. CD8(+) T activation attenuates CD4(+)T proliferation through dendritic cells modification. Cell Immunol.2015;296(2):138-48.

7. Liu X, Ji B, Sun M, Wu W, Huang L, Sun A, Zong Y, Xia S, Shi L, Qian H, Xu W, ShaoQ. Cell-penetrable mouse forkhead box protein 3 alleviates experimentalarthritis in mice by up-regulating regulatory T cells. Clin Exp Immunol.2015;181(1):87-99.

8. Li Y, Ji X, Su Z, Tong J, Xia S, Chen X, Lu P, Barnie PA, Wang S, Huang X, Xu H.Downregulation of Runx3 is closely related to the decreased Th1-associatedfactors in patients with gastric carcinoma. Tumour Biol. 2014;35(12):12235-44..

9. Liu X, Zhao Q, Peng X, Xia S, Shen W, Zong Y, Cheng J, Wu W, Zhang M, Du F, Xu W,Qian H, Shao Q. PTD-mediated intracellular delivery of mutant NFAT minimum DNAbinding domain inhibited the proliferation of T cells. Int Immunopharmacol.2014;19(1):110-8

10. Xia S*, Li X, Cheng L, Han M, Zhang M, Liu X, Xu H, Zhang M, Shao Q, Qi L. Chronicintake of high fish oil diet induces myeloid-derived suppressor cells topromote tumor growth. Cancer Immunol Immunother. 2014;63(7):663-73.  

11. Xia S*, Han M, Li X, Cheng L, Qiang Y, Wu S, Zhang M, Xu H, Liu X, Shao Q. Dietaryfish oil exacerbates concanavalin A induced hepatitis through promotinghepatocyte apoptosis and altering immune cell populations. J Toxicol Sci.2014;39(2):179-90.  

12. Sha H, Yang L, Liu M, Xia S, Liu Y, Liu F, Kersten S, Qi L. Adipocyte spliced formof X-box-binding protein 1 promotes adiponectin multimerization and systemicglucose homeostasis. Diabetes. 2014;63(3):867-79.

13. Gu Y, Yang P, Shao Q, Liu X, Xia S, Zhang M, Xu H, Shao Q. Investigation of theexpression patterns and correlation of DNA methyltransferases and class Ihistone deacetylases in ovarian cancer tissues. Oncol Lett. 2013;5(2):452-458.

14. Tong J, Han Q, Wang S, Su Z, Zheng D, Shen P, Xia S, Huang X, Shao Q, Xu H.Corynebacterium pyruviciproducens, as an immune modulator, can promote theactivity of macrophages and up-regulate antibody response to particulateantigen. Exp Biol Med (Maywood).2012;237(11):1322-30.

15. Sun S, Xia S, Ji Y, Kersten S, Qi L. The ATP-P2X7 signaling axis is dispensable forobesity-associated inflammasome activation in adipose tissue. Diabetes.2012;61(6):1471-8.

16. Xu X, Yi H, Guo Z, Qian C, Xia S, Yao Y, Cao X. Splenic stroma-educated regulatorydendritic cells induce apoptosis of activated CD4 T cells via FasL-enhancedIFN-[gamma] and nitric oxide. J Immunology. 2012 188 (3): (3):1168-77

17. Liu X, Xu X, Lin X, Tian Y, Ji B, Xia S, Xu S, Yin Q, Zhang M, Jiao Z, Wang S, XuH, Shao Q. PTD-hFOXP3 protein acts as an immune regulator to convert humanCD4(+)CD25(-) T cells to regulatory T-like cells. J Cell Biochem.2012;113(12):3797-809.

18. Ji Y, Sun S, Xia S, Yang L, Li X, Qi L. Short term high fat diet challengepromotes alternative macrophage polarization in adipose tissue via naturalkiller T cells and interleukin-4. J Biol Chem. 2012;287(29):24378-86

19. Qingzhen H, Jia T, Shengjun W, Yang Z, Yanfang L, Pei S, Essien BS, Zhaoliang S, ShengX, Qixiang S, Finegold SM, Xu H. Corynebacterium pyruviciproducens promotes theproduction of ovalbumin specific antibody via stimulating dendritic celldifferentiation and up-regulating Th2 biased immune response. Vaccine.2012;30(6):1115-23

20. He Z, Shotorbani SS, Jiao Z, Su Z, Tong J, Liu Y, Shen P, Ma J, Gao J, Wang T, XiaS, Shao Q, Wang S, Xu H. HMGB1 promotes the differentiation of Th17 viaup-regulating TLR2 and IL-23 of CD14+ monocytes from patients with rheumatoidarthritis. Scand J Immunol. 2012 Nov;76(5):483-90.

21.Xia S*, Sha H, Yang L, Ji Y, Ostrand-Rosenberg S, Qi L. Gr-1+CD11b+ myeloid-derivedsuppressor cells suppress inflammation and promote insulin sensitivity inobesity. J Biol Chem. 2011, 286: (26):23591-9.