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马洁

马洁

女,博士,教授,硕士生导师。现任江苏大学医学院检验医学实验室副主任、医学院教工第四党支部宣传委员,兼任中华医学会微生物与免疫分会青年委员、江苏省医学微生物与免疫学会委员。

长期从事临床生物化学检验工作,曾在美国University of MarylanPostdoctoral)从事免疫学研修工作。科研方向主要集中在免疫调节与自身免疫性疾病、树突状细胞生物学功能以及肿瘤免疫学治疗等方面。

作为课题负责人主持国家自然科学基金1项、中国博士后基金、江苏省博士后基金1项、江苏省重点实验室课题1项、江苏大学高级人才项目1项、江苏大学青年基金扶持项目1。近年来以第一作者和通讯作者Am J PatholMolecular OncologyJ Clin Endocrinol Metab Cancer LettsSCI期刊发表论文36篇,主持和参加的科研成果有4项通过省市科技鉴定,获省部级科技进步奖1项、市厅级科技进步奖3项。主编、参编教材9部。培养和指导博士、硕士研究生5名。

主持或参加科研项目及人才计划项目情况:

1. GITRL 调控Tfh 细胞促进小鼠胶原诱导性关节炎发病的实验研究, 国家自然科学基金(31100648),项目负责人

2. 髓源性抑制细胞来源的exosomes 抑制小鼠胶原诱导性关节炎的实验研究,国家自然科学基金(31470881),参与

3. 长链非编码RNA作为肺癌早期预测标志物的实验及临床研究,,江苏省重点实验室开放课题(JSKLM-2014-013),项目负责人

4. 长链非编码RNA通过调控粒系髓源性抑制细胞影响小鼠肺癌抗瘤免疫应答的实验研究,江苏大学青年基金扶持项目(FCJJ2015022),项目负责人

5. mGITRL调控Tfh细胞功能及在CIA中的作用机制,江苏大学高级人才项目(11JDG093),项目负责人

发表主要论文:

一、第一作者论文

1. Ma J(马洁), Xu H, Wang S. Immunosuppressive Role of Myeloid-Derived Suppressor Cells and Therapeutic Targeting in Lung Cancer. J Immunol Res. 2018 Mar 25;2018:6319649. doi: 10.1155/2018/6319649. eCollection 2018. Review. SCI IF 3.298

2. Ma J(马洁), Guarnera MA, Zhou W, Fang H, Jiang F. A Prediction Model Based on Biomarkers and Clinical Characteristics for Detection of Lung Cancer in Pulmonary Nodules. 2017, Transl Oncol, 10(1): 40-45. SCI IF 2.392

3. Ma Jie (马洁), Tian Jie, Wang Shengjun, Blockade of GITR signaling ameliorates murine collagen-induced arthritis by modulating follicular helper T cellsAm J Pathol, 2016. 186(6): 1559-1567.SCI IF 4.591

4. Ma J(马洁), Li N, Lin Y, Gupta C, Jiang F. Circulating Neutrophil MicroRNAs as Biomarkers for the Detection of Lung Cancer. Biomark Cancer. 2016 Jan 24; 8:1-7. doi: 10.4137/BIC.S37333.

5. Ma, Jie(马洁), Lin, Yanli, Zhan Min, Mann Dean LStass Sanford AJiang, FengDifferential miRNA expressions in peripheral blood mononuclear cells for diagnosis of lung cancer, Laboratory Investigation, 2015, 95(10): 1197-1206. SCI IF 3.676

6. Ma J(马洁) , Mannoor K, Gao L, Tan A, Guarnera MA, Zhan M, Shetty A, Stass SAXing L, Jiang F, Characterization of microRNA transcriptome in lung cancer by next-generation deep sequencing, Mol Oncol, 2014, 8(7):1208-1219. SCI IF 5.331

7. Li N, Ma J(马洁)(共同第一作者) , Guarnera MA, Fang H, Cai L, Jiang F, Digital PCR quantification of miRNAs in sputum for diagnosis of lung cancer, Cancer Res Clin Oncol, 2014, 140(1):145-150. SCI IF 3.081

8. Gao L, Ma J(马洁)(共同第一作者)  , Mannoor K, Guarnera MA, Shetty A, Zhan M, Xing L, Stass SA, Jiang FGenome-wide small nucleolar RNA expression analysis of lung cancer by next-generation deep sequencingInt J Cancer, 2014, 136(6):623-629. SCI IF 5.085

9. Ma J(马洁) , Li N, Guarnera M, Jiang F, Quantification of Plasma miRNAs by Digital PCR for Cancer Diagnosis, Biomark Insights, 2013, 14(8):127-136.

10. Ma Jie(马洁) , Zhu Chenlu, Ma Bin, Tian Jie, Baidoo Samuel Essien, Mao Chaoming, Wu Wei, Chen Jianguo, Tong Jia, Yang Min, Jiao Zhijun, Xu Huaxi, Lu Liwei, Wang Shengjun, Increased Frequency of Circulating Follicular Helper T Cells in Patients with Rheumatoid ArthritisClin Dev Immunol, 2012;2012:827480. doi: 10.1155/2012/827480. SCI IF 2.934

11.  Zhu Chenlu, Ma Jie(马洁)(共同第一作者), Liu Yingzhao, Tong Jia, Tian Jie, Chen Jianguo, Tang  Xinyi, Xu Huaxi, Lu Liwei, Wang Shengjun, Increased Frequency of Follicular Helper T Cells in Patients with Autoimmune Thyroid DiseaseJournal of Clinical Endocrinology &Metabolism, 2012, 97(3):943-950. SCI IF 6.209

12.  Ma J(马洁) , Wang S, Ma B, Mao C, Tong J, Yang M, Wu C, Jiao Z, Lu L, Xu H, Dendritic cells engineered to express GITRL enhance therapeutic immunity in murine Lewis lung carcinoma, Cancer Lett, 2011, 301(2):142-150. SCI IF 5.621

13. Tian J, Ma J(马洁)(共同第一作者) , Wang S, Yan J, Chen J, Tong J, Wu C, Liu Y, Ma B, Mao C, Jiao Z, Shao Q, Lu L, Xu H, Increased expression of mGITRL on D2SC/1 cells by particulate β-glucan impairs the suppressive effect of CD4(+)CD25(+) regulatory T cells and enhances the effector T cell proliferation, Cell Immunol, 2011, 270(2):183-187. SCI IF 1.924

二、通讯作者论文

1. Chen Juan, Ma Jie(马洁)(共同通讯作者), Tian Jie, Tang Xinyi, Rui Ke, Mao Chaoming, Liu Yingzhao, Lu Liwei, Xu Huaxi, Wang Shengjun, MiR-346 regulates CD4(+)CXCR5(+) T cells in the pathogenesis of Graves' diseaseEndocrine, 2015, 49(3):752-760. SCI IF 3.878

三、既非第一作者又非通讯作者论文

1. Zhou Q, Tang X, Tian X, Tian J, Zhang Y, Ma J(马洁), Xu H, Wang S. LncRNA MALAT1 negatively regulates MDSCs in patients with lung cancer. J Cancer. 2018 Jun 14;9(14):2436-2442. doi: 10.7150/jca.24796. eCollection 2018.

2. Tian X, Ma J(马洁), Wang T, Tian J, Zheng Y, Peng R, Wang Y, Zhang Y, Mao L, Xu H, Wang S. Long non-coding RNA RUNXOR accelerates MDSC-mediated immunosuppression in lung cancer. BMC Cancer. 2018 Jun 18;18(1):660. doi: 10.1186/s12885-018-4564-6.

3. Tian X, Ma J(马洁), Wang T, Tian J, Zhang Y, Mao L, Xu H, Wang S. Long Non-Coding RNA HOXA Transcript Antisense RNA Myeloid-Specific 1-HOXA1 Axis Downregulates the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells in Lung Cancer. Front Immunol. 2018 Mar 12;9:473. doi: 10.3389/fimmu.2018.00473. eCollection 2018.

4. Peng HuiyongLiu YingzhaoTian JieMa Jie(马洁),Tang XinyiRui KeTian Xinyu, Mao Chaoming, Lu Liwei, Xu Huaxi, Jiang Pengcheng, Wang Shengjun. The Long Noncoding RNA IFNG-AS1 Promotes T HelperType 1 Cells Response in Patients with Hashimoto's Thyroiditis. Scientific Reports, 2015 Dec 4;5:17702. doi:

10.1038/srep17702.

5. Tian Jie, Rui Ke, Tang Xinyi, Ma Jie(马洁),Wang Yungang, Tian Xinyu, Zhang Yue, Xu Huaxi, Lu Liwei, Wang Shengjun. MicroRNA-9 Regulates the Differentiation and Function of Myeloid-Derived Suppressor Cells via Targeting Runx1. The Journal of Immunology, 2015, 195(3):1301-1311.

6. Peng Huiyong, Liu Yingzhao, Tian Jie, Ma Jie(马洁), Tang Xinyi, Yang Jun, Rui Ke, Zhang Yue, Mao Chaoming, Lu Liwei, Xu Huaxi, Wang Shengjun. Decreased expression of microRNA-125a-3p upregulates interleukin-23 receptor in patients with Hashimoto's thyroiditis. Immunologic Research, 2015, 62(2):129-136.

7. Yuan Jing, Tang Xinyi, Yin Kai, Tian Jie, Rui Ke, Ma Jie(马洁),Mao Chaoming, Chen Jianguo, Lu Liwei, Xu Huaxi, Wang Shengjun. GITRL as a genetic adjuvant enhances enterovirus 71 VP1 DNA vaccine immunogenicityImmunologic Research, 2015, 62(1):81-88.

8. Tian Xinyu, Tian Jie, Tang Xinyi, Rui Ke, Zhang Yue, Ma Jie(马洁), Wang Yungang, Xu Huaxi, Lu Liwei, Wang Shengjun. Particulate beta-glucan regulates the immunosuppression of granulocytic myeloid-derived suppressor cells by inhibiting NFIA expression. Oncoimmunology,2015 Jul 1;4(9):e1038687.

9. Liu Yingzhao, Tang Xinyi, Tian Jie, Zhu Chenlu, Peng Huiyong, Rui Ke, Wang Yungang, Mao Chaoming, Ma Jie(马洁), Lu Liwei, Xu Huaxi, Wang Shengjun. Th17/Treg Cells Imbalance and GITRL Profile in Patients with Hashimoto's ThyroiditisInternational Journal of Molecular Sciences, 2014, 15(12):21674-21686.

10. Tian Jie, Zhang Yue, Yang Xiaomin, Rui Ke, Tang Xinyi, Ma Jie(马洁), Chen, Jianguo, Xu Huaxi, Lu Liwei, Wang Shengjun, Ficus carica Polysaccharides Promote the Maturation and Function of Dendritic CellsInternational Journal of Molecular Sciences, 2014, 15(7):12469-12479.

11. Liu Y, Tang X, Tian J, Zhu C, Peng H, Rui K, Wang Y, Mao C, Ma J(马洁), Lu L, Xu H, Wang S. Th17/Treg Cells Imbalance and GITRL Profile in Patients with Hashimoto's Thyroiditis. Int J Mol Sci, 2014, 15(12):21674-21686.

12. Tian JieMa Jie(马洁), Ma Ke, Guo Hongye, Baidoo Samuel Essien, Zhang Yue, Yan, JunLu Liwei, Xu Huaxi, Wang Shengjun. beta-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic

myeloid-derived suppressor cells. European Journal of Immunology, 2013, 43(5): 1220-1230.

13. Wang S, Baidoo S. E, Liu Y, Zhu C, Tian J, Ma J(马洁),Tong J, Chen J, Tang X, Xu H, Lu L. T cell-derived leptin contributes to increased frequency of T helper type 17 cells in female patients with Hashimoto';s thyroiditisClinical and Experimental Immunology. 2013,171(1):63-68.

14. Tian J, Ma J(马洁), Ma K, Guo H, Baidoo SE, Zhang Y, Yan J, Lu L, Xu H, Wang S. β-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cellsEur J Immunol, 2013, 43(5):1220-1230.

15. Tian Jie, Ma Jie(马洁), Ma Ke, Ma Bin, Tang Xinyi, Baidoo Samuel Essien, Tong Jia, Yan Jun, Lu Liwei, Xu Huaxi, Wang Shengjun. Up-Regulation of GITRL on Dendritic Cells by WGP Improves Anti-Tumor Immunity in Murine Lewis Lung Carcinoma. PLOS ONE, 2012, 7(10):e46936.

16. He Z, Shotorbani S. Sm Jiao Z, Su Z, Tong, Liu Y, Shen P, Ma J(马洁),Gao J, Wang T, Xia S, Shao Q, Wang S, XuH. HMGB1 Promotes the Differentiation of Th17 via Up-Regulating TLR2 and IL-23 of CD14+Monocytes from Patients with Rheumatoid Arthritis. Scandinavian Journal of Immunology, 2012, 76(5):483-490.

17. Wang Shengjun, Shi Ye, Yang Min, Ma Jie(马洁), Tian Jie, Chen Jianguo, Mao Chaoming, Jiao Zhijun, Ko King-Hung, Baidoo Samuel Essien, Xu Huaxi, Hua Zichun, Lu Liwei. Glucocorticoid-Induced Tumor Necrosis Factor Receptor Family-Related Protein Exacerbates Collagen-Induced Arthritis by Enhancing the Expansion of Th17 Cells. Am J Pathol, 2012, 180(3):1059-1067.

18. Tian J, Ma J(马洁), Ma K, Ma B, Tang X, Baidoo SE, Tong J, Yan J, Lu L, Xu H, Wang S. Up-regulation of GITRL on dendritic cells by WGP improves anti-tumor immunity in murine Lewis lung carcinoma. PLoS One, 2012, 7(10):46936.

19. Jiao Z, Wang W, Ma J(马洁) , Wang S, Su Z, Xu H. Notch signaling mediates TNF-α-induced IL-6 production in cultured fibroblast-like synoviocytes from rheumatoid arthritis. Clin Dev Immunol, 2011, 350209.

20. Dawei Cui, Shengjun Wang, Yu Chen, Jia Tong, Jie Ma(马洁), Li Tang, Xianzhi Yang, Ye Shi , Jie Tian, Liwei Lu, Huaxi Xu. An Isoleucine Zipper Motif Enhances Costimulation of Human Soluble Trimeric GITR ligand. Cell Mol Immunol, 2010,7(4) 316-322.

21. Chaoming Mao, Shengjun Wang, Qian Jiang, Jia Tong, Jie Ma(马洁), Min Yang, Xiaopeng Xu, Gufeng Qiu, Qixiang Shao, Long Li,Huaxi Xu. Increased CD4+CD25+FOXP3+ Regulatory T Cells in Cancer Patients from Conversion of CD4+CD25- T Cells through Tumor-derived Factors. Oncologie, 2008,31(5) 243-248.

22. Wang SJ, Xu HX, Wang YZ, Ma J(马洁), Mao CM, Shao QX, Ma B, Xu WR, Yang SL. Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice. International Journal of Molecular Medicine, 2006; 18(6): 1193-1200.