杨大凯,副教授,硕士生导师,分子生物学及检验教研室,邮箱:yangdakai@126.com
【学习工作经历】
本硕就读于南京中医药大学,药剂专业,后留学乌普萨拉大学及汉诺威医学院,分别获得生物医学硕士学位和分子医学博士学位。博士毕业后,在斯坦福大学从事再生医学博士后研究。
【教改科研项目】
主持国家自然科学基金青年基金1项(82100666)
主持江苏省自然科学基金青年基金1项(BK20200906)
参与教育部高等教育智慧教育平台课程《分子生物学与医药》,2022
参与教育部产学合作协同育人项目“《临床分子生物学检验》AI课程体系与教学模式的创新研究与实践”,2022
【代表性论文】
1.Yang D, Liu J. Neutrophil Extracellular Traps: A New Player in Cancer Metastasis and Therapeutic Target. J Exp Clin Cancer Res. 2021 Jul 16;40(1):233.
2.Yang D*, Dai Z*, Yang T, Balakrishnan A, Yuan Q, Vondran FWR, Manns MP, Ott M, Cantz T, Sharma AD. MicroRNA-125b-5p Regulates Hepatocyte Proliferation During the Termination Phase of Liver Regeneration. Hepatol Commun.2020 Sep 15;4(12):1851-1863.
3.Yang D, Liu J. Targeting extracellular vesicles-mediated hepatic inflammation as a therapeutic strategy in liver diseases. Liver Int. 2020 Sep;40(9):2064-2073.
4.Yang D, Yuan Q, Balakrishnan A, Bantel H, Klusmann JH, Manns MP, Ott M, Cantz T, Sharma AD. MicroRNA-125b-5p mimic inhibits acute liver failure. Nat Commun. 2016 Jun 23;7:11916.
5.Möbus S, Yang D, Yuan Q, Lüdtke TH, Balakrishnan A, Sgodda M, Rani B, Kispert A, Araúzo-Bravo MJ, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD. MicroRNA-199a-5p inhibition enhances the liver repopulation ability of human embryonic stem cell-derived hepatic cells. J. Hepatol. 2015 Jan;62(1):101-110.
【教材与专著】
专著:
Yang D, Möbus S, Balakrishnan A, Sharma AD. MicroRNAs in liver regeneration. MicroRNA in Regenerative Medicine (Book Chapter).Elsevier, 2014: 943-965.
参编教材:
执业检验医师(技师)应试题集与解答 上海科学技术出版社 2023.1
【获奖与专利】
获奖:
2020年“人卫杯”医学检验教育教学优秀论文三等奖
2018-2019 Stanford Dean’s fellowship ($26,700)
2016 Chinese Government Outstanding Overseas PhD Prize ($ 6,000)
2015/2016 HBRS Best PhD Prize (€1,000)
2003/2004 Chinese National Scholarship (¥ 10,000)
专利:
European Patent of Medicament for the treatment of acute liver failure (PCT/EP2017/062997)
【荣誉与兼职】
1. American Heart Association (AHA) Member
2. German Stem Cell Network (GSCN) Member
3. Reviewer of The Journal of Pathology