梁照锋，副教授，硕士生导师，临床生物化学教研室，

邮箱：liangzhaofeng@ujs.edu.cn

【学习工作经历】

(1) 2019-6至今,江苏大学,医学院,副教授

(2) 2017-7至今,江苏大学,医学院,硕士生导师

(3) 2017-7至2019-5,江苏大学,医学院,讲师

【教改科研项目】

1.国家自然科学基金委员会，青年科学基金项目，Wnt/β-catenin通路在吸烟增强胃癌干细胞干性中的作用及姜黄素的干预研究，已结题，主持。

2.国家博士后基金委，面上项目，Wnt/β-catenin通路在吸烟增强胃癌干细胞干性中的机制，已结题，主持。

3.江苏大学，青年英才培育计划，胃癌干细胞外泌体在胃癌发生发展中的作用及机制研究，在研，主持。

4.镇江市重点研发计划-社会发展，重点（医卫）项目，外泌体转运circ0004873在MNNG促进胃癌发生中的作用及机制研究，在研，主持。

5.国家科学技术部，重点基础研究发展计划(973计划)（新型肿瘤相关蛋白的致癌机理及其应用基础研究）子课题，TP63蛋白调控EMT及在肺癌转移中的作用研究，已结题，参与。

6.国家自然科学基金委员会，面上项目，MAPK信号通路在吸烟诱导的肺上皮细胞分化异常中的作用及其干预研究，已结题，参与。

【代表性论文】

1) Hao Geng^#, Qingchen Zhou^#, Wenhao Guo, Ling Lu, Liangkuan Bi, Yi Wang, Jie Min, Dexin

Yu*,Zhaofeng Liang*. Exosomes in bladder cancer: novel biomarkers and targets. J Zhejiang

Univ-SC B. 2021;22(5):341-347(封面文章).

2)Zhaofeng Liang^#, Wenhao Guo^#, Shikun Fang, Yue Zhang, Ling Lu, Wenrong Xu*, Hui Qian*. CircRNAs: Emerging Bladder Cancer Biomarkers and Targets. Front Oncol. 2021;10:606485 (SCI一区).

3) Ling Lu^#, Qiaoyan Liang^#, Shiyue Shen, Lei Feng, Longtao Jin*,Zhao Feng Liang*. Tobacco Smoke Plays an Important Role in Initiation and Development of Lung Cancer by Promoting the Characteristics of Cancer Stem Cells. Cancer Manag Res. 2020;12:9735-9739(SCI二区).

4) Ling Lu, Jia Chen, Manli Li, Ling Tang, Rui Wu, Longtao Jin*,Zhaofeng Liang*. β-carotene reverses tobacco smoke-induced gastric EMT via Notch pathway in vivo. Oncol Rep, 201839(4):1867-1873.

5)Zhaofeng Liang^#, Rui Wu^#, Wei Xie, Mingming Zhu, Chunfeng Xie, Xiaoting Li, Jianyun

Zhu, Weiwei Zhu, Jieshu Wu, Shanshan Geng, Wenrong Xu, Caiyun Zhong*, Hongyu Han*.

Curcumin reverses tobacco smoke induced epithelial mesenchymal transition by suppressing the

MAPK pathway in the lungs of mice. Mol Med Rep, 2018, 17(1):2019-2025.

6)Zhaofeng Liang^#, Ling Lu^#, Jiahui Mao, Xia Li, Hui Qian*, Wenrong Xu*. Curcumin reversed chronic tobacco smoke exposure induced urocystic EMT and acquisition of cancer stem cells properties via Wnt/β-catenin. Cell Death Dis, 2017, 8(10):e3066(SCI一区).

7) Jiahui Mao^#,Zhaofeng Liang^#, Bin Zhang^#, Huan Yang, Xia Li, Hailong Fu, Xu Zhang, Yongmin Yan, Wenrong Xu*, Hui Qian*. UBR2 Enriched in p53 Deficient Mouse Bone Marrow

Mesenchymal Stem Cell-Exosome Promoted Gastric Cancer Progression via Wnt/β-Catenin Pathway. Stem Cells, 2017, 35(11):2267-2279(SCI一区).

8) Zhaofeng Liang, Rui Wu, Wei Xie, Chunfeng Xie, Jieshu Wu, Shanshan Geng, Xiaoting Li,

Mingming Zhu, Weiwei Zhu, Jianyun Zhu, Cong Huang, Xiao Ma, Wenrong Xu, Caiyun Zhong*,

Hongyu Han*. Effects of curcumin on tobacco smoke-induced hepatic MAPK pathway activation

and epithelial-mesenchymal transition in vivo. Phytother Res, 2017, 31(8):1230-1239(SCI二区).

9) Ling Lu, Jia Chen, Hua Tang, Ling Bai, Chun Lu, Kehuan Wang, Manli Li, Yinmei Yan, Ling

Tang, Rui Wu, Yang Ye, Longtao Jin*,Zhaofeng Liang*. EGCG Suppresses ERK5 Activation to

Reverse Tobacco Smoke-Triggered Gastric Epithelial-Mesenchymal Transition in BALB/c Mice.

Nutrients, 2016, 8(7): pii: E380(SCI一区).

10)Zhaofeng Liang, Rui Wu, Wei Xie, Hao Geng, Li Zhao, Chunfeng Xie, Jieshu Wu, Shanshan Geng, Xiaoting Li, Mingming Zhu, Weiwei Zhu, Jianyun Zhu, Cong Huang, Xiao Ma, Caiyun Zhong*, Hongyu Han*. Curcumin Suppresses MAPK Pathways to Reverse Tobacco Smoke-induced Gastric Epithelial-Mesenchymal Transition in Mice. Phytother Res, 2015, 29(10):1665-1671(SCI二区).

【教材与专著】

1）《外泌体：组织损伤修复与肿瘤诊治》，科学出版社，副主编；

2）《临床生物化学检验》，科学出版社，编委、秘书；

3）《临床生物化学检验实验指导》，中国医药科技出版社，编委、秘书。

【荣誉与兼职】

江苏省检验医学会青年委员；

中国毒理学会会员；

中国营养学会会员。

Frontiers in Oncology编委、Journal of Advanced Research、Cell Death & Disease、Frontiers in Pharmacology、Frontiers in Neurology等杂志审稿人。