王华，副教授，硕士生导师，微生物检验教研室，邮箱：wangjiahan1979@163.com

【学习工作经历】

2006-至今，江苏大学医学院，讲师/副教授

2016-2017，University of British Columbia访问学者

2006-2011，江苏大学博士研究生

【教改科研项目】

1.校企合作，消化道多病原检测方法的建立，2022-2026（20220921，30万，主持，在研）。

2.国家自然基金青年基金，幽门螺杆菌IV型分泌系统CagI及CagQ蛋白功能研究，2014-2016，（81301396，23万，主持，结题）。

3.江苏省自然基金青年基金，幽门螺杆菌IV型分泌系统两种伴侣蛋白的功能研究，2013-2016，（BK20130542，20万，主持，结题）。

4.中国博士后基金，幽门螺杆菌IV型分泌系统CagX、CagI及CagQ蛋白功能研究，2013-2015，（2013M531290，5万，主持，结题）。

【代表性论文】

（1）Tingjun Liu^#,, Yuhan Li^#,, Shengjie Chen^#,, Lulu Wang, Xiaolan Liu, Qingru Yang, Yan Wang, Xiaorong Qiao, Jing Tong, Xintao Deng, Shihe Shao, Hua Wang*, Hongxing Shen*. CircDDX17 enhances coxsackievirus B3 replication through regulating miR-1248/NOTCH receptor 2 axis. Front Microbiol. 2022; 13: 1012124.

（2）Qingru Yang^#, Yuhan Li^#, Yan Wang, Xiaorong Qiao, Tingjun Liu, Hua Wang*, Hongxing Shen*. The circRNA circSIAE Inhibits Replication of Coxsackie Virus B3 by Targeting miR-331-3p and Thousand and One Amino-Acid Kinase 2. Front Cell Infect Microbiol. 2022; 11: 779919.

（3）Hua Wang^#, Yajing Lin^#, Jingpeng Jin, Hongxing Shen* , Chun Daid*. Nuclear Pore Complex 62 Promotes Metastasis of Gastric Cancer by Regulating Wnt/β-Catenin and TGF-β Signaling Pathways. J Environ Pathol Toxicol Oncol. 2021; 40(2):81-87.

（4）Yongjiang Qian, Xufeng Pu, Yu Yu, Xintian Yu, Liang Kong, Lu Liu, Hua Wang*, Hongxing Shen*. Poliovirus serotype 2 and coxsackievirus A promote thenatural recombination of poliovirus. J Med Virol. 2020; 92(3): 263–270.

（5）Hua Wang^#*, Fanyu Meng^#, Surong Dong*. Aberrant Expression of Gastric Carcinoma High Expressed Transcript 1 is a Diagnostic and Prognostic Biomarker in Human Cancer. J Natl Med Assoc. 2020; 112(6): 602-612.

（6）Hua Wang, Yongjiang Qian, Chunhua Qian, Chun Dai*, Hongxing Shen*. Two Natural Recombination gave rise to the Coxsackievirus B3 GVthat triggered outbreaks in China in 2006 – 2012. Infect Dis Now, 2021; 51(1): 81-85.

（7）Hua Wang^#, Surong Dong^#, Yun Liu, Feng Ma, Jian Fang, Wentao Zhang, Shihe Shao, Hongxing Shen*, Jingpeng Jin*. DAB2 suppresses gastric cancer migration by regulating the Wnt/β-catenin and Hippo-YAP signaling pathways. Transl Cancer Res. 2020; 9(2): 1174-1184.

（8）Yizheng Yao, Yixin Shen, Linqi Zhu, Ying Ni, Hua Wang*, Shihe Shao*. Preliminary study and bioinformatics analysis on the potential role of CagQ in type Ⅳ secretion system of H.pylori. Microb Pathog. 2018; 116:1-7.

（9）Hongxing Shen, Tingjun Liu, Yucheng Luo, Shihe Shao, Xintao Deng*, Hua Wang*. Echovirus plays major roles in the natural recombination of Coxsackievirus B3. J Med Virol. 2018; 90(2):377–382.

（10）Hua Wang, Yizheng Yao, Bin Ni, Yixin Shen, Xiaochun Wang, Hongxing Shen*, Shihe Shao*. Helicobacter pylori CagI is associated with the stability of CagA. Microb Pathog. 2016; 99:130-134.