生秀梅，教授，硕士生导师，医学生物化学教研室主任，主要从事病原菌致病分子机制及肿瘤发生发展机制的研究。邮箱：shengxiumei@ujs.edu.cn

【学习工作经历】

2017.05-至今，江苏大学，医学院基础医学系，教授

2013.05-2014.05，美国德克萨斯大学MD安德森癌症中心，访问副教授

2011.08-2017.04，江苏大学，医学院基础医学系，副教授

2005.08-2011.07，江苏大学，医学技术学院，讲师

2003.09-2005.06，华中师范大学研究生学报，兼职编辑

1999.08-2005.07，江苏大学，医学院，助教

2006.09-2009.12，江苏大学，博士

2002.09-2005.07，华中师范大学，硕士

1995.09-1999.07，华中师范大学，学士

【教改科研项目】

1．江苏省自然科学基金面上项目，BK20191429，GLIPR1抑制肺癌生长的分子机制及靶向治疗研究，在研，主持；

2.国家博士后基金面上项目，2015M571702，Mig-14参与伤寒沙门菌致病机制研究，结题，主持；

3．国家青年自然科学基金项目，31000046、Mig-14参与伤寒沙门菌耐多粘菌素B机制研究，已结题，主持；

4．江苏大学高级人才启动基金项目，11JD063、Mig-14参与伤寒沙门菌耐药机制研究，在研，主持；

5．江苏省教育厅项目，08KJD310012、高渗应激下PhoP与OmpR交叉调节伤寒沙门菌基因表达，已结题，主持。

【代表性论文】

1.Wang JJ, Li ZY, Yin FF, Zhang R, Zhang Y, Wang ZX*,Sheng XM*, Glioma pathogenesis-related protein 1 performs dual functions in tumor cells, Cancer gene therapy, 2021, online ahead of print. doi: 10.1038/s41417-021-00321-9.

2.Altayyar MA,Sheng XM, Wang ZX. WD repeat domain 77 protein regulates translation of E2F1 and E2F3 mRNA. Mol. Cell Biol. 2020, 40(24): e00302-20.

3.Lu W, Cao FH, Wang SJ,Sheng XM*, Ma J*. LncRNAs: The Regulator of Glucolipid Metabolism in Tumor Cells.Front. Oncol. 9: 1099. doi: 10.3389/fonc.2019.01099.

4.Sheng XM, Wang WW, Chen L, Zhang H, Zhang Y, Xu SG, Xu HX, Huang XX. Mig-14 may contribute toSalmonella entericaserovar Typhi resistance to polymyxin B by decreasing the permeability of the outer-membrane and promoting the formation of biofilm. International Journal of Medical Microbiology, 2019, 309(2):143～150. (SCI收录)

5.Sheng XM, Bowen N, Wang ZX. GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer. Mol Cancer. 2016, 15(1):25. (SCI收录)

6.Sheng XM, Wang ZX. Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation. BMC cancer. 2016, 16: 567.

7.Sheng XM, Zhang H, XiaQF, et al. Mig-14 plays an important role in influencing gene expression of salmonella enterica serovar Typhi, which contributes to cell invasion under hyperosmotic conditions. Research in Microbiology. 2013, 903～912. (SCI收录)

8.Sheng XM, Xu SG, Lu RY, et al. Design of a comprehensive biochemistry and molecular biology experiment: Phase variation caused by recombinational regulation of bacterial gene expression. Biochemistry and molecular biology education. 2014, 224～229. (SCI收录)

9.Sheng XM, Huang XX, Mao LX, et al. Preparation of salmonella enteric servor Typhi genomic DNA microarrays for gene expression profiling analysis. Prog. Biochem. Biophy, 2009, 36(2): 206～212(SCI收录)

10.Sheng XM, Huang XX, Li JH, et al. Regulation of sulphur assimilation pathways insalmonella enterica serovar Typhi upon up-shift high osmotic treatment: the role of UhpA revealed through transcriptome profiling. Curr Microbiol. 2009, 59: 628～635. (SCI收录)

【获奖与专利】

生秀梅，黄新祥，徐顺高等.伤寒沙门菌DNA芯片转录表达谱用基因组特异引物. 200910031165.4已授权