Date of Birth

Research Area
Immunology and Microbiology,1. Dendritic cells and autoimmune diseases.2. Bacteria gene diagnosis and innate immunity.3. Food nutrition and Immunity.

Primary Course

Professinal Education
Hua-xi Xu, PhD, Professor

SHORT BIOGRAPHY

Professor, Vice president of Jiangsu University. He is a Ph.D supervisor, the pace-setter of the provincial key academic discipline of clinical examination diagnosis and enjoys the state council special allowance, Director of Institute of Clinical Laboratory Medicine，Academic leader of Qinglan Project of Jiangsu province. He is the executive member of Chinese Society of Immunology ( the deputy chairman of the Jiangsu Society of Immunology ), the executive member of Chinese Society of Microbiology, vice chief member of Jiangsu Society of Microbiology and Immunology of Chinese Medical association, and member of the Ministry of Public Health Guiding Committee of College Medical Textbook Construction. Besides, he is the editor-in-chief of Journal of Jiangsu University ( Medicine Edition ), member of the editing board of Shiyong Laonian Yixue and Chinese Pharmacological Bulletin. He has supervised 18 doctoral candidates and more than 20 master’s degree candidates.

Academic Introduction
EDUCATION BACKGROUND

PhD (1998.1-2011.7), Regeneration and Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu, Japan
M.S (1987.9-1990.12), Medical Microbiology and Immunology, Dalian Medical University, Dalian, China
B.S (1978.3-1981.1), Clinical Medicine, Zhenjiang Medical College, Zhenjiang, China

PROFESSIONAL POSITIONS

2009.10~Present Professor, Academic Leader, Vice-President, Jiangsu University, China
2009.7~2009.10 Visiting Scholar, Division of Experimental Immunology and Immunopathology, Department of pathology, University of Louisville, Louisville, KY，USA
2001.8~2009.7 Professor, Academic Leader, Vice-President, Jiangsu University, Director of Institute of Laboratory Medicine, China
2001.8~2000.1 Professor, Academic Leader, Vice-President, Director of Department of Immunology，Institute of Laboratory Medicine Zhenjiang Medical College, China
2000.1~1998.3 Visiting Scholar, Department of Microbiology, Regenerationand Advanced Medical Science, Gifu University Graduate School of Medicine, Gifu, Japan
1998.3~1997.9 Vice- Professor, Dean of Department of Medical Examination, Zhenjiang Medical College, China
1997.9~1994.9 Lecturer, Department of Microbiology and Immunology, Zhenjiang Medical College, China
1994.9~1981.3 Teaching assistant, Department of Microbiology and Immunology, Zhenjiang Medical College, China

Scientific Research Item and Achievement
CURRENT RESEARCH PROJECTS
1. Study on monoclonal antibody to dendritic cell. National Natural Science Fundation of China. Project No.39370364
2. Application of dendritic cell carrying T-bet gene in Bronchial asthma. National Natural Science Fundation of China. Project No.30471627
3. Molecular mechanism of Th17 cell differentiation induced by GITRL. National Natural Science Fundation of China. Project No.30972748
4. Establishment of dendritic cell line co-transfected by T-bet and Hlx genes. National Natural Science Fundation of China. Project No.30710103093
5. Study on the effect of Treg cell induced by gene-modified dendritic cell in EAT tratment. National Natural Science Fundation of China. Project No.30300169
6. Molecular mechanism of Th17 cell differentiation induced by Leptin and its effect in EAT. National Natural Science Fundation of China. Project No.30871193
7. Study on the Prevention and Treatment of transplant rejection using the method of combine traditional Chinese and western medicine. National Natural Science Fundation of China. Project No.39070750
8. Establishment of chemical carcinogens detecting system in vitro. National Natural Science Fundation of China. Project No.39070727
9. Study on the security of Silkworm expression system utilizing in genetic engineering. National Project 863, Project No. 102-11-02-06
10. Study on establishment and application of new detacting method of bacterial DNA similarity . Natural Science Fundation of Jiangsu province. Project No. BK2000029
11. Mechanism study on Kolmogorov Corynebacterium induce Th subsets differentiation and the effect on mastitis pathogenesis. Young Scholars of National Natural Science Fundation of China. Project No.81101227
12. Mechanism study on Th17 cell increase in the number induced by HMGB1 in EAM mice. Young Scholars of National Natural Science Fundation of China. Project No.81001319

Publications
MAIN PUBLICATIONS EMBODIED BY SCI IN RECENT YEARS
1. HMGB 1 blockade attenuates experimental autoimmune myocarditis possibly by suppressing Th17-cell expansion. Eur J Immunol. 2011 Sep 19. doi: 10.1002/eji.201141879.
2. Increased expression of mGITRL on D2SC/1 cells by particulate ?-glucan impairs the suppressive effect of CD4(+)CD25(+) regulatory T cells and enhances the effector T cell proliferation. Cell Immunol. 2011;270(2):183-7
3. Changes and significance of IL-25 in chicken collagen II-induced experimental arthritis (CIA). Rheumatol Int. 2011 May 29.
4. Molecular characterization of a functional type VI secretion system in Salmonella enterica serovar Typhi. Curr Microbiol. 2011;63(1):22-31.
5. Comparison of prognostic value of two kinds of severity scoring systems for hospital mortality prediction on elderly patients with acute kidney injury. Aging Clin Exp Res. 2011 Apr 4.
6. Application of quantitative real-time PCR for rapid identification of Bacteroides fragilis group and related organisms in human wound samples. Anaerobe. 2011;17(2):64-8
7. The Th17/Treg imbalance and cytokine environment in peripheral blood of patients with rheumatoid arthritis. Rheumatol Int. 2011 Jan 11.
8. Dendritic cells engineered to express GITRL enhance therapeutic immunity in murine Lewis lung carcinoma. Cancer Lett. 2011 Feb 28;301(2):142-50.
9. Mesenchymal stem cells isolated from human uterine cervix cancer tissues. Cell Biol Int. 2011;35(2):119-23
10. RpoE may promote flagellar gene expression in Salmonella enterica serovar typhi under hyperosmotic stress. Curr Microbiol. 2011;62(2): 492-500.
11. Herbaspirillum species: a potential pathogenic bacteria isolated from acute lymphoblastic leukemia patient. Curr Microbiol. 2011;62(1):331-3.
12. Immunologic mapping of glycomes: implications for cancer diagnosis and therapy. Front Biosci (Schol Ed). 2011;3:1520-32
13.The rag locus of Porphyromonas gingivalis might arise from Bacteroides via horizontal gene transfer. Eur J Clin Microbiol Infect Dis. 2010;29(4):429-37.
14.A Potential Pathogenic Bacteria Isolated from Acute Lymphoblastic Leukemia Patient. Curr Microbiol. 2010 Jul 13.
15.Epidemiology of hand, foot, and mouth disease and genotype characterization of Enterovirus 71 in Jiangsu, China. J Clin Virol. 2010 Oct;49(2):100-4. 2010 Aug 16.
16.An isoleucine-zipper motif enhances costimulation of human soluble trimeric GITR ligand. Cell Mol Immunol. 2010;7(4):316-22.
17.Novel function of B cell-activating factor in the induction of IL-10-producing regulatory B cells. J Immunol. 2010; 1;184(7):3321-5
18.DNMT3B Promoter Polymorphism and Risk of Gastric Cancer. Dig Dis Sci. 2010;55(4):1011-6
19.Differentiation Imbalance of Th1? Th17 in Peripheral Blood Mononuclear Cells Might Contribute to Pathogenesis of Hashimoto’s Thyroiditis. Scandinavian Journal of Immunology 2010;72:250–255.
20.The mutations of Th1 cell-speci?c T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancers. International Journal of Immunogenetics 2010; 37:111–115.
21.Corynebacterium pyruviciproducens sp. nov., a pyruvic acid producer. Int J Syst Evol Microbiol. 2010 May;60(Pt 5):1135-40.
22.Salicylic acid enhances biocontrol ef?cacy of Rhodotorula glutinis against postharvest Rhizopus rot of strawberries and the possible mechanisms involved. Food Chemistry. 2010; 122 577–583
23. Changes of Iron Stores and Duodenal Transepithelial Iron Transfer During Regular Exercise in Rats. Biol Trace Elem Res. 2010 Dec 21
24.Four novel resistance integron gene-cassette occurrences in bacterial isolates from zhenjiang, china. Curr Microbiol. 2009 Aug;59(2):113-7.
25.Identification and characterization of class 1 integrons among Pseudomonas aeruginosa isolates from patients in Zhenjiang, China. Int J Infect Dis. 2009 Nov;13(6):717-21.
26.Leptin signaling protects NK cells from apoptosis during development in mouse bone marrow. Cell Mol Immunol. 2009;6(5):353-60.
27.Identification of a fljA gene on a linear plasmid as the repressor gene of fliC in Salmonella enterica serovar Typhi. Microbiol Immunol. 2009;53(4):191-7
28.Increased frequencies of T helper type 17 cells in the peripheral blood of patients with acute myeloid leukaemia Clinical and Experimental Immunology, 2009?158: 199–204.
29.Serum proteome alteration of severe sepsis in the treatment of continuous renal replacement therapy. Nephrol Dial Transplant. 2009; 24:3108-3114.
30.Methyl jasmonate enhances biocontrol ef.cacy of Rhodotorula glutinis to postharvest blue mold decay of pears. Food Chemistry. 2009;117:621–626
31.Identification of a fljA gene on a linear plasmid as the repressor gene of fliC in Salmonella enterica serovar Typhi. Microbiol Immunol. 2009;53(4):191-7
32.The blaCTX-M-1gene located in a novel complex classI integron bearing an ISCR1 element in E. coli isolates from Zhenjiang, China. J Antimicrob Chemother. 2008 Jul 21.
33.Tat-mediated Intracellular Delivery of T-bet Protein into THP-1 Cells can Induce Th1-Type Response.Immunological Investigations,2008;37:97 –111
34.Intranasal delivery of T-bet gene modulates the profile of T helper cell immune responses in a mouse model of allergic asthma. J Investig Allergol Clin Immunol, Vol 18 (5) :357-65, 2008
35.Increased CD4CD25+FOXP3+ regulatory T Cells in cancer patients from conversion of CD4+CD25-T cells through tumor-derived factors. Onkologie. 2008 May;31 (5) :243-8.
36.Transcriptional expression of fljB:z66, a flagellin gene located on a novel linear plasmid of Salmonella enterica serovar Typhi under environmental stresses. New Microbiol. 2008 Apr;31(2):241-7.
37.Natural killer cell degeneration exacerbates experimental arthritis in mice via enhanced interleukin-17 production. Arthritis Rheum. 2008 Sep;58 (9):2700-11.
38.Improved prediction of coreceptor usage and phenotype of HIV-1 based on combined features of V3 loop sequence using random forest. J Microbiol. 2007 Oct;45(5):441-6.
39.Avian Influenza: Should China Be Alarmed? Yonsei Medical Journal, 2007 Aug 31;48(4):586-94
40.Mutations in Helicobacter pylori porD and oorD Genes May Contribute to Furazolidone Resistance. Croat Med J. 2006 Jun;47(3):410-5.
41.Regulatory T cells induced by rAAV carrying the forkhead boxP3gene prevent autoimmune thyroiditis in mice. Int J Mol Med. 2006 Dec;18(6):1193-9.
42.Virulence-defective strains of Salmonella enterica serovar Typhi as candidates for education at level 2 facilities. Microbiol Immunol. 2006;50(4):273-9.