Date of Birth

Research Area
physiology

Primary Course

Professinal Education
Dr. Yongchang Chen is a professor of physiology and the chairman of the Department of Physiology of Jiangsu University. He graduated from Suzhou Medical College and received his bachelor degree in 1983, graduated from Nanjing Medical College and received his master degree in 1990, and graduated form Beijing University and received his Ph.D. in 2000.

Academic Introduction
He has been engaged in teaching and researching of physiology for more than twenty five years. With passion to physiology, he got huge teaching experience and contributed to the publication of six textbooks of physiology. He has undertaken the teaching of physiology for thousands of students and received excellent results. He has been nominated as the chairman of the department of physiology since 1995 and made big contribution to the development of the course of physiology in Jiangsu University..

Scientific Research Item and Achievement
He received several awards from the university and was the candidate of “333” program of Jiangsu Province. He also has senior experience in physiological research. From 1993－1994, he visited Linkoping University of Sweden as a visiting scholar. From 2000-2003, he did his postdoctoral research in University of California, San Diego (UCSD). From 2008-2010, he visited UCSD again as a visiting professor of UCSD. He has published more than thirty research articles, including 15 SCI papers. His doctoral research paper 《Synergism between Calcium and cGMP in CRE-dependent transcriptional regulation requires cooperation between CREB and C/EBP-related proteins》was published on “Molecular and Cellular Biology （MCB）”. He received Science and Technology Award of Jiangsu Province in 2003, and received Natural Science Award of Ministry of Education in 2008. He has presided two National Natural Science Foundation projects and one project of Natural Science Foundation of Jiangsu Province. His present research direction is in “intracellular signal transduction network”. He is presiding one project of National Natural Science Foundation now.

Publications
Published papers：
Chen Y., Zhuang S., Cassenaer S., et al. Synergism between Calcium and cGMP in CRE-dependent transcriptional regulation requires cooperation between CREB and C/EBP-related proteins. Mol Cell Bio, 2003, 23:4066-82
Chen Y., Wang Y., Yu H., et al. The cross talk between protein kianse A- and RhoA-mediated signaling in cancer cells. Experimental Biology and Medicine, 2005, 230:731-741
Chen Y., Wang Y., Xu W., et al. Analysis on the mechanism of Helicobacter pylori-induced apoptosis in gastric cancer cell line BGC-823. International Journal of Molecular Medicine, 2005, 16: 741-745
Chen Y. C., Wang Y, Li J Y, et al. H pylori stimulates proliferation of gastric cancer cells through activating mitogen-activated protein kinase cascade. World Journal of Gastroenterology , 2006, 12: 5972-5977.
Wang Y, Chen Y, Xu W, et al. AKAPs competing peptide HT31 disrupts the inhibitory effect of PKA on RhoA activity. Oncol Rep, 2006, 16:755-761

Tao Y, Chen Y, Wang Y, et al. Phosphorylated vasodilator-stimulated phosphoprotein is localized on mitotic spindles of the gastric cancer cell line SGC-7901. World J Gastroenterol, 2006, 12:7478-7481

Tao Y, Chen Y, Li Y, et al. Localization and translocation of RhoA protein in the human gastric cancer cell line SGC-7901. World J Gastroenterol, 2008, 14:1175-1181

Chen YC, Ren F, Sang JR, et al. Type II cGMP-dependent protein kinase inhibits
proliferation of the gastric cancer cell line BGC-823. Mol Med Rep, 2010, 3:361-366

Yan Tao, Yong-ChangChen, Jian-RongSang and Wen-Rong Xu. Phosphorylation of vasodilator stimulated phosphoprotein is correlated with cell cycle progression in HeLa cells. Molecular Medicine Reports 2010, 3: 657-662,

Yueying Li, Yongchang Chen, Yan Tao, Jin Xu and Miao Chen. RhoA protein is generally distributed in the nuclei of cancer cells. Oncology Reports 2010, 24: 1005-1009

Yongjin Li, Yongchang Chen, Yan Tao, Ying Wang, Yuefang Chen and Wenrong Xu. Fibronectin increases RhoA activity through inhibition of PKA in the human gastric cancer cell line SGC-7901. Molecular Medicine Reports 2011, 4: 65-69,

Yan Wu, Yong-Chang Chen, Jian-Rong Sang and Wen-Rong Xu. RhoC protein stimulates migration of gastric cancer cells through interaction with scaffold protein IQGAP1. Molecular Medicine Reports 2011, 4: 697-703

Yueying Li, Yongchang Chen and Jin Xu. Factors influencing RhoA protein distribution in the nucleus. Molecular Medicine Reports 2011, 4: 1115-1119