江苏大学医学院，医学博士，副教授，博士生导师
研究方向：从事间质干细胞与胃癌的基础与临床研究，研究分析胃癌间质干细胞转分化促进胃癌淋巴结转移分子机制，致力于寻找靶向微环境细胞阻断胃癌进展潜在治疗靶点及胃癌诊疗检测新指标。
Email：wangmei8417@163.com
教育经历：
2007/9 - 2012/6，江苏大学，临床检验诊断学专业，研究生，医学博士
2002/9 - 2007/7，江苏大学，医学检验专业，本科，医学学士
工作经历：
2021/1-至今，江苏大学，临床检验与输血学教研室，副教授，博士生导师
2015/7 -2020/12，江苏大学，临床检验与输血学教研室，副教授，硕士生导师
2014/1 - 2015/6，江苏大学，临床检验与输血学教研室，讲师，硕士生导师
2012/6 - 2013/12，江苏大学，临床检验与输血学教研室，讲师
主持或参加科研项目及人才计划项目情况：
主持科研项目
1. 国家自然基金面上项目，81772641，区域淋巴结转移胃癌exosome重塑骨髓MSC作用及其分子机制，2018/01-2021/12, 58万
2. 中国博士后科学基金面上项目，2017M611740，骨髓MSC促淋巴结转移胃癌恶化作用及其分子机制，2017/05-2018/11, 5 万
3. 江苏省博士后基金，1701027A，淋巴结转移胃癌exosome重塑骨髓MSC促胃癌作用及机制，2017/10-2019/05， 6万
4. 国家自然基金青年基金，81302119，胃癌MSC 源性miRNAs 再编程骨髓MSC 作用及机制研究，2014/01-2016/12， 23万
5. 江苏省自然科学基金，BK20130540，microRNA再编程骨髓间质干细胞转分化及机制研究，2013/06-2016/07，20万
6. 江苏省普通高校自然科学研究项目，13KJB320001，microRNA 调控骨髓MSC向胃癌MSC转分化及机制研究，2013/08-2015/12，3.2万
7. 江苏大学“青年骨干教师培养工程”青年学术带头人 2014/01-2017/12 6万
参与科研项目
1. 江苏省社会发展重大研发项目(临床前沿技术)，BE2017694, 胃癌MSC促进PD-1/PD-L1免疫治疗耐药机制及转化医学研究，2017/07-2020/06，200万 排名2
2. 国家自然基金面上项目，81472334，胃癌MSC源性细胞因子调节Th17/ Treg细胞分化作用机制及其临床应用，2015/01-2018/12，70 万 排名3
3. 国家自然基金面上项目，81071421，GC-MSC和癌组织来源的MicroRNAs
在胃癌诊治中的作用，2011/01-2013/12，36万 排名2
4. 江苏省科技厅临床医学科技专项，BL2012055，癌相关间质干细胞源性miRNA分析技术在胃癌分子诊断中的应用，2012/01-2015/12，100万 排名2
发表代表性论文列表如下：(#, co-author; *, corresponding author)
1. Wang M*, Zhao X, Qiu R, Gong Z, Huang F, Yu W, Shen B, Sha X, Dong H, Huang J, Wang L, Zhu W, Xu W. Lymph node metastasis-derived gastric cancer cells educate bone marrow-derived mesenchymal stem cells via YAP signaling activation by exosomal Wnt5a. Oncogene, 2021, doi: 10.1038/s41388-021-01722-8. (IF:7.971)
2. Wang M*, Zhao X, Huang F, Wang L, Huang J, Gong Z, Yu W. Exosomal proteins: Key players mediating pre‑metastatic niche formation and clinical implications. Int J Oncol, 2021, doi: 10.3892/ijo.2021.5184. (IF:3.899)
3. Wang M*, Gong Z, Zhao X, Yu W, Huang F, Dong H. Circular RNAs emerge as important regulators with great potential for clinical application in gastric cancer. Biomark Med, 2021,15(1):69-82. (IF:2.479)
4. Wang M*,#, Zhang H#, Yang F#, Qiu R, Zhao X, Gong Z, Yu W, Zhou B, Shen B, Zhu W. miR-188-5p suppresses cellular proliferation and migration via IL6ST: A potential noninvasive diagnostic biomarker for breast cancer, J Cell Physiol, 2020, 235 (5), 4890-4901. (IF:5.546)
5. Sun L#, Huang C#, Zhu M, Guo S, Gao Q, Wang Q, Chen B, Li R, Zhao Y, Wang M, Chen Z, Shen B, Zhu W*. Gastric cancer mesenchymal stem cells regulate PD-L1-CTCF enhancing cancer stem cell-like properties and tumorigenesis. Theranostics, 2020, 10(26):11950-11962. (IF:8.579)
6. Wang M*, Qiu R, Gong Z, Zhao X, Wang T, Zhou L, Lu W, Shen B, Zhu W, Xu W. miR-188-5p emerges as an oncomiRNA to promote gastric cancer cell proliferation and migration via upregulation of SALL4, J Cell Biochem, 2019, 120(9):15027-15037. (IF:4.237)
7. Wang M, Qiu R, Yu S, Xu X, Li G, Gu R, Tan C, Zhu W, Shen B*. Paclitaxel‑resistant gastric cancer MGC‑803 cells promote epithelial‑to‑mesenchymal transition and chemoresistance in paclitaxel‑sensitive cells via exosomal delivery of miR‑155‑5p, Int J Oncol, 2019, 54(1):326-338. (IF:3.899)
8. Wang M*, Yang F, Qiu R, Zhu M, Zhang H, Xu W, Shen B, Zhu W. The role of mmu-miR-155-5p-NF-κB signaling in the education of bone marrow-derived mesenchymal stem cells by gastric cancer cells. Cancer Med, 2018, 7(3):856-868. (IF:3.491)
9. Wang Q, Li Z, Sun L, Chen B, Zhao Y, Shen B, Zhu M, Zhao X, Xu C, Wang M, Xu W, Zhu W*. Platelets enhance the ability of bone-marrow mesenchymal stem cells to promote cancer metastasis. Onco Targets Ther, 2018,11:8251-8263. (IF:3.337)
10. Sun L, Wang Q, Chen B, Zhao Y, Shen B, Wang H, Xu J, Zhu M, Zhao X, Xu C, Chen Z, Wang M, Xu W, Zhu W*. Gastric cancer mesenchymal stem cells derived IL-8 induces PD-L1 expression in gastric cancer cells via STAT3/mTOR-c-Myc signal axis. Cell Death Dis, 2018, 9(9):928. (IF:6.484)
11. Chen B#, Yu J#, Wang Q, Zhao Y, Sun L, Xu C, Zhao X, Shen B, Wang M, Xu W, Zhu W*. Human Bone Marrow Mesenchymal Stem Cells Promote Gastric Cancer Growth via Regulating c-Myc. Stem Cells Int, 2018, 2018:9501747. (IF:3.869)
12. Sun L, Wang Q, Chen B, Zhao Y, Shen B, Wang X, Zhu M, Li Z, Zhao X, Xu C, Chen Z, Wang M, Xu W, Zhu W*. Human Gastric Cancer Mesenchymal Stem Cell-Derived IL15 Contributes to Tumor Cell Epithelial-Mesenchymal Transition via Upregulation Tregs Ratio and PD-1 Expression in CD4+T Cell. Stem Cells Dev, 2018, 27(17):1203-1214. (IF:3.153)
13. Xu R, Zhao X, Zhao Y, Chen B, Sun L, Xu C, Shen B, Wang M, Xu W, Zhu W*. Enhanced gastric cancer growth potential of mesenchymal stem cells derived from gastric cancer tissues educated by CD4+ T cells, Cell Prolif, 2018, 51(2):e12399. (IF:5.753)
14. Wang M, Chen B, Sun XX, Zhao XD, Zhao YY, Sun L, Xu CG, Shen B, Su ZL, Xu WR, Zhu W*. Gastric cancer tissue-derived mesenchymal stem cells impact peripheral blood mononuclear cells via disruption of Treg/Th17 balance to promote gastric cancer progression, Exp Cell Res, 2017, 361(1):19-29. (IF:3.383)
15. Qian H, Ding X, Zhang J, Mao F, Sun Z, Jia H, Yin L, Wang M, Zhang X, Zhang B, Yan Y, Zhu W, Xu W*. Cancer stemness and metastatic potential of the novel tumor cell line K3: an inner mutated cell of bone marrow-derived mesenchymal stem cells. Oncotarget, 2017, 8(24):39522-39533. (IF:5.168)
16. Zhu M#, Wang M#,*, Yang F, Tian Y, Cai J, Yang H, Fu H, Mao F, Zhu W, Qian H, Xu W*. miR-155-5p inhibition promotes the transition of bone marrow mesenchymal stem cells to gastric cancer tissue derived MSC-like cells via NF-κB p65 activation, Oncotarget, 2016, 7(13):16567-16580. (IF:5.168)
17. Cai J#, Wang M#, Zhu M, Zhang Q, Zhang X, Yan Y, Qian H, Xu W*. N-methyl-N-nitro-N'-nitrosoguanidine induces the expression of CCR2 in human gastric epithelial cells promoting CCL2-mediated migration, Mol Med Rep, 2016, 13(2):1083-1090. (IF:2.1)
18. Wang M#, Cai J#, Huang F#, Zhu M, Zhang Q, Yang T, Zhang X, Qian H, Xu W*. Pre-treatment of human umbilical cord-derived mesenchymal stem cells with interleukin-6 abolishes their growth-promoting effect on gastric cancer cells, Int J Mol Med, 2015,35(2):367-375. (IF:3.098)
19. Zhang B#, Wang M#, Gong A#, Zhang X, Wu X, Zhu Y, Shi H, Wu L, Zhu W, Qian H*, Xu W*. HucMSC-exosome mediated-Wnt4 signaling is required for cutaneous wound healing, Stem Cells, 2015, 33(7):2158-2168. (IF:6.022)
20. Ji R#, Zhang B#, Zhang X, Xue J, Yuan X, Yan Y, Wang M, Zhu W, Qian H*, Xu W*. Exosomes derived from human mesenchymal stem cells confer drug resistance in gastric cancer, Cell Cycle, 2015, 14(15):2473-2483 (IF:3.699)
21. Wang M#, Zhao C#, Shi H, Zhang B, Zhang L, Zhang X, Wang S, Wu X, Yang T, Huang F, Cai J, Zhu Q, Zhu W, Qian H*, Xu W*. Deregulated microRNAs in gastric cancer tissue-derived mesenchymal stem cells: novel biomarkers and a mechanism for gastric cancer, Br J Cancer, 2014, 110(5):1199-1210. (IF:6.210)
22. Huang F#, Wang M#, Yang T, Cai J, Zhang Q, Sun Z, Wu X, Zhang X, Zhu W, Qian H*, Xu W*. Gastric cancer-derived MSC-secreted PDGF-DD promotes gastric cancer progression, J Cancer Res Clin Oncol, 2014,140(11):1835-1848. (IF:3.656)
23. Zhu Q#, Zhang X#,*, Zhang L, Li W, Wu H, Yuan X, Mao F, Wang M, Zhu W, Qian H, Xu W*. The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression, Cell Death Dis, 2014, 5:e1295. (IF:6.484)
24. Yang T#, Zhang X#, Wang M, Zhang J, Huang F, Cai J, Zhang Q, Mao F, Zhu W, Qian H*, Xu W*. Activation of mesenchymal stem cells by macrophages prompts human gastric cancer growth through NF-κB pathway, PLoS One, 2014, 9(5):e97569 (IF:2.815)
25. Zhang L#, Xu Z#, Xu X, Zhang B, Wu H, Wang M, Zhang X, Yang T, Cai J, Yan Y, Mao F, Zhu W, Shao Q, Qian H*, Xu W*. SALL4, a novel marker for human gastric carcinogenesis and metastasis, Oncogene, 2014,33(48):5491-5500. (IF:7.971)
26. Zhang Q#, Wang M#, Huang F, Yang T, Cai J, Zhang X, Zhu W, Qian H*, Xu W*. H. pylori infection-induced MSC differentiation into CAFs promotes epithelial-mesenchymal transition in gastric epithelial cells, Int J Mol Med, 2013, 32(6): 1465-1473. (IF:3.098)
27. Wang M, Gu H, Qian H, Zhu W, Zhao C, Zhang X, Tao Y, Zhang L, Xu W*. miR-17-5p/20a are important markers for gastric cancer and murine double minute 2 participates in their functional regulation, Eur J Cancer, 2013, 49(8):2010-2021. (IF:7.275)
28. Wang M, Gu H, Wang S, Qian H, Zhu W, Zhang L, Zhao C, Tao Y, Xu W*. Circulating miR-17-5p and miR-20a: molecular markers for gastric cancer, Mol Med Rep, 2012, 5(6):1514-1520. (IF:2.1)
29. Zhu W, Huang L, Li Y, Zhang X, Gu J, Yan Y, Xu X, Wang M, Qian H, Xu W*. Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo, Cancer Lett, 2012, 315(1):28-37. (IF:7.360)
30. Xu X#, Zhang X#, Wang S, Qian H, Zhu W, Cao H, Wang M, Chen Y, Xu W*. Isolation and comparison of mesenchymal stem-like cells from human gastric cancer and adjacent non-cancerous tissues, J Cancer Res Clin Oncol, 2011, 137(3):495-504. (IF:3.656)
31. Xu X#, Qian H#, Zhu W, Zhang X, Yan Y, Wang M, Xu W*. Isolation of cancer stem cells from transformed human mesenchymal stem cell line F6, J Mol Med (Berl), 2010, 88(11):1181-1190. (IF:4.427)
获奖情况：
1. 2019年获中华医学会科技奖二等奖，江苏省科技奖三等奖、江苏省医学会科技奖一等奖
2. 2016年获镇江市优秀科技论文一等奖
3. 2016年获镇江市优秀科技论文三等奖
4. 2015年获临床应用生物化学与分子生物学分会2015年学术年会青年学者学术论文二等奖
5. 2014年获江苏大学第七届教师教学竞赛新教师组三等奖
6. 2014年获江苏大学“青年骨干教师培养工程”青年学术带头人培育人选称号
7. 2013年获镇江市优秀科技论文一等奖
