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田洁

江苏大学,医学院,博士生导师,副教授

澳大利亚国立大学访问学者

江苏省六大人才高峰高层次人才

江苏省科协青年科技人才托举工程

江苏大学优秀青年骨干教师

主讲课程:

本科:《免疫学》,《免疫学及免疫学检验》,《Immunology》(留学生)

研究生:《免疫学技术》,《医学免疫学》

研究方向:

自身免疫性疾病的机制及治疗;肿瘤免疫

学术兼职:

江苏省免疫学会理事,江苏省免疫学会转化医学专业委员会常务委员,Member of American Association of Immunologists

主持或参加科研项目及人才计划项目情况(按时间倒序排序):

1. 国家自然科学基金(面上项目),81971542,致病性MDSCs通过调控B细胞应答参与小鼠实验性干燥综合征的机制研究,2020/01-2023/1255万元,在研,主持。

2. 国家自然科学基金(青年基金),81601424GITRL/GITR信号通过调控MDSCs参与小鼠实验性干燥综合征的机制研究,2017/01-2019/1217万元,已结题,主持。

3. 江苏省自然科学基金(青年基金),BK20150533,小鼠 ESS 发病过程中 GITRL对髓源性抑制细胞的调控作用,2015/07-2018/0620.0万元,已结题,主持。

4. 中国博士后特别资助项目,2017T100336间充质干细胞通过调控MDSCs抑制ESS的机制研究2017/07-2019/1215万元,在研,主持。

5. 中国博士后科学基金项目,2016M590423GITRL对髓源性抑制细胞的调控的信号通路研究,2016/07-2018/068.0万元,已结题,主持。

6. 江苏大学高级人才科研启动基金,15JDG070miR-9 对髓源性抑制细胞的分化及功能的调控研究,2015/01-2017/125.0万元,已结题,主持。

7. 江苏省六大人才高峰高层次人才项目,YY-006,间充质干细胞的外泌体治疗原发性干燥综合征的研究,2018/01-2020/124万元,在研,主持。

8. 江苏大学青年英才培育计划2017/01-2019/1210.0万元,主持。

发表SCI论文:(#第一作者,*通讯作者)

1. Tian J#, Rui K#, Hong Y, Wang X, Xiao F, Lin X, Ma J, Guo H, Xu H, Ma K, Xu D, Liu D, Zhao Y, Lu L*, and Wang S*. Increased GITRL Impairs the Function of Myeloid-Derived Suppressor Cells and Exacerbates Primary Sjögren Syndrome. The Journal of Immunology. 2019;202(6):1693-703. ESI高被引,Top期刊)

2. Tian J#, Rui K#, Tang X, Ma J, Wang Y, Tian X, Zhang Y, Xu H, Lu L, and Wang S*. MicroRNA-9 regulates the differentiation and function of myeloid-derived suppressor cells via targeting Runx1. The Journal of Immunology. 2015; 195(3):1301-1311.Top期刊)

3. Tian J, Ma J, Ma K, Guo H, Baidoo SE, Zhang Y, Yan J, Lu L, Xu H, and Wang S*. β-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cells. European Journal of Immunology. 2013; 43(5):1220-1230.

4. Zheng Y, Tian X, Wang T, Xia X, Cao F, Tian J*, Xu P*, Ma J, Xu H, Wang S*. Long noncoding RNA Pvt1 regulates the immunosuppression activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice. Mol Cancer. 2019;18(1):61. IF 10.679, Top期刊,中科院JCR一区)

5. Lu J, Wu J, Xie F, Tian J*, Tang X, Guo H, Ma J, Xu P*, Mao L*, Xu H, Wang S*. CD4(+) T Cell-Released Extracellular Vesicles Potentiate the Efficacy of the HBsAg Vaccine by Enhancing B Cell Responses. Adv Sci. 2019;6(23):1802219. IF 15.804, Top期刊,中科院JCR一区)

6. Tian J#, Rui K#, Tang X#, Wang W, Ma J, Tian X, Wang Y, Zhang Y, Xu H*, Lu L*, and Wang S*. IL-17 down-regulates the immunosuppressive capacity of olfactory ecto-mesenchymal stem cells in murine collagen-induced arthritis. Oncotarget. 2016; 7(28) : 42953-42962.

7. Tian J, Ma J, Ma K, Ma B, Tang X, Baidoo SE, Tong J, Yan J, Lu L, Xu H, and Wang S*. Up-regulation of GITRL on dendritic cells by WGP improves anti-tumor immunity in murine Lewis lung carcinoma. PLoS ONE. 2012; 7(10):e46936.

8. Tian J, Zhang Y, Yang X, Rui K, Tang X, Ma J, Chen J, Xu H, Lu L, and Wang S*. Ficus carica Polysaccharides promote the maturation and function of dendritic cells. International Journal of Molecular Sciences. 2014; 15(7):12469-12479.

9. Tian J, Rui K, and Wang S*. Roles of miRNAs in regulating the differentiation and maturation of myeloid-derived suppressor cells. Medical Hypotheses. 2014; 83(2):151-153.

10. Tian J#, Ma J#, Wang S*, Yan J*, Chen J, Tong J, Wu C, Liu Y, Ma B, Mao C, Jiao Z, Shao Q, Lu L, Xu H. Increased expression of mGITRL on D2SC/1 cells by particulate β-glucan impairs the suppressive effect of CD4+CD25+ regulatory T cells and enhances the effector T cell proliferation. Cellular Immunology. 2011; 270(2):183-187.

11. Tian X#, Tian J#, Tang X, Rui K, Zhang Y, Ma J, Wang Y, Xu H, Lu L, Wang S*. Particulate β-glucan regulates the immunosuppression of granulocytic myeloid-derived suppressor cells by inhibiting NFIA expression. Oncoimmunology. 2015; 4(9):e1038687.Top期刊,中科院JCR一区)

12. Tian X#, Tian J#, Tang X, Ma J, Wang S*. Long non-coding RNAs in the regulation of myeloid cells. Journal of Hematology & Oncology. 2016; 9(1):99. (Review)Top期刊,中科院JCR一区)

13. Rui K#, Tian J#, Tang X, Ma J*, Xu P*, Tian X, Wang Y, Xu H, Lu L, and Wang S*. Curdlan blocks the immune suppression by myeloid-derived suppressor cells and reduces tumor burden. Immunologic Research. 2016; 64(4):931-939.

14. Wang J#, Peng H#, Tian J*#, Ma J, Tang X, Rui K, Tian X, Wang Y, Chen J, Lu L, Xu H, Wang S*. Upregulation of long noncoding RNA TMEVPG1 enhances T helper type 1 cell response in patients with Sjögren syndrome. Immunologic Research. 2016; 64(2):489-496.

15. Peng H#, Liu Y#, Tian J*#, Ma J, Tang X, Yang J, Rui K, Zhang Y, Mao C, Lu L, Xu H, Wang S*. Decreased expression of microRNA-125a-3p upregulates interleukin-23 receptor in patients with Hashimoto’s thyroiditis. Immunologic Research. 2015; 62(2):129-136.

16. Yuan J#, Tang X#, Yin K#, Tian J*, Rui K, Ma J, Mao C, Chen J, Lu L, Xu H, Wang S*. GITRL as a genetic adjuvant enhances enterovirus 71 VP1 DNA vaccine immunogenicity. Immunologic Research. 2015; 62(1):81-88.

17. Wang J#, Zhang Y#, Yin K#, Xu P, Tian J*, Ma J, Tian X, Wang Y, Tang X, Xu H, Wang S*. IL-17A weakens the antitumor immunity by inhibiting apoptosis of MDSCs in Lewis lung carcinoma bearing mice. Oncotarget. 2017; 8(3):4814-4825.

18. Tang X#, Yin K#, Zhu H#, Tian J*, Shen D, Yi L, Rui K, Ma J, Xu H, Wang S*. Correlation between the expression of microRNA-301a-3p and the proportion of Th17 cells in patients with rheumatoid arthritis. Inflammation. 2016; 39(2):759-767.

19. Tang X, Wang J, Xia X, Tian J*, Rui K, Xu H, Wang S*. Elevated expression of ciRS-7 in peripheral blood mononuclear cells from rheumatoid arthritis patients. Diagn Pathol. 2019;14(1):11.

20. Wang Y, Tian J*, Wang S*. The potential therapeutic role of myeloid-derived suppressor cells in autoimmune arthritis. Seminars in Arthritis and Rheumatism. 2016; 45(4):490-495. Review

21. Wu X, Tian J*, Wang S*. Insight into non-pathogenic Th17 cells in autoimmune diseases. Frontiers in Immunology. 2018; 9:1112. (Review)

22. Li M, Zhu D, Wang T, Xia X, Tian J*, Wang S*. Roles of Myeloid-Derived Suppressor Cell Subpopulations in Autoimmune Arthritis. Frontiers in Immunology. 2018; 9:2849. (Review)

23. Lu J, Wu J, Tian J*, Wang S*. Role of T cell-derived exosomes in immunoregulation. Immunologic Research. 2018;66(3):313-322. (Review)

获得学术奖励荣誉

1. 田洁2/9),甲状腺疾病发病新机制及干预策略研究,江苏省人民政府,江苏省科学技术奖,三等奖,2018

2. 田洁2/10),天然β-葡聚糖双向抗瘤免疫新机制,中国商业联合会,中国商业联合会科技进步奖,三等奖,2017

3. 田洁2/5),类风湿性关节炎发病新机制研究,江苏省教育厅,江苏省教育教学与研究成果奖(研究类),二等奖,2018

4. 田洁3/3),外周循环MDSC在原发性干燥综合征中的检测及临床应用,江苏省卫生健康委,江苏省医学新技术引进奖,一等奖,2019

5. 田洁2/5),类风湿性关节炎发病新机制及干预策略研究,江苏省医学会,江苏医学科技奖,三等奖,2018

6. 田洁 3/5),自身免疫性甲状腺疾病患者新型CD4+辅助性T细胞亚群检测及临床意义,江苏省医学会,江苏医学科技奖,三等奖,2014

7. 田洁3/5),Th17细胞参与类风湿性关节炎发病的机制研究,镇江市人民政府,镇江市科技进步奖,二等奖,2016

8. 田洁7/7),GITRL调控机体Treg/Th17细胞增强抗肿瘤免疫应答的研究,江苏省人民政府,江苏省科学技术奖,三等奖,2012

9. 田洁1/1),江苏大学奋达杰出青年英才奖,江苏大学,三等奖,2018

10. 田洁1/1),β-葡聚糖对髓源性抑制细胞的分子调控及其在抗瘤免疫中的作用,江苏省学位委员会,江苏省优秀博士论文,2015

专利:

1. 田洁 3/8,一种粒细胞样髓源性抑制细胞来源exosomes及其应用,2017.10.20,国家发明专利,ZL 201510072238.X,申报国际PCT专利PCT/CN2015/077902)。