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Wenrong Xu

Date of Birth
1963

Research Area
1. Basic Research and Clinical Application of Stem cells,2. Stem cells, Tumorigenesis and Molecular Diagnostic Techniques ,3. Stem cell associated factors and their Clinical Significances,4. Clincial Laboratory Hematology and Molecular Biology.

Primary Course

Professinal Education
Personal Information:
Wenrong Xu.
Dean, Professor, Ph.D. MD.
School of Medical Science and Laboratory Medicine
Jiangsu University, Zhenjiang, Jiangsu, P. R. China. Post Code: 212013
Phone: (+86) 511-85038419 (H)
(+86) 511-85038215 (O)
Cell phone: (+86) 13605283151

Academic Introduction
Education:
2011.6-2011.11 Visiting scholar, Health Medicine Center, Texas Tech University, in USA.
2010.7- 2011.9: Visiting Scholar, University of Maryland in USA.
2001.9-2004.6: Ph.D. in Cellular and Molecular Biology, Nanjing Normal University, P.R.China. Major in mesenchymal stem cells.
1987.9-1990.12: Master in Immnuohematology, Nanjing Medical University, P.R. China. Major in cytokins and hematopoietic stem cells.
1980.9-1982.12: B. in Laboratory Medicine, Zhenjiang Medical School, P.R. China. Major in clinical laboratory medicine.

Achievements and honors:
Cross-Century Head of Science and Technology of Colleges and Universities of “333 Projects” in Jiangsu.
Excellent Teacher and Researcher of Colleges and Universities, in Jiangsu.
Jiangsu Province’s Outstanding Medical Academic Leader have been awarded by Jiangsu province government.
Main program contributor: “Mesenchymal stem cell and their clinical application”.

Scientific Research Item and Achievement
Current Funding:
1. A Grant from the Major Programs of National Natural Science Foundation of China. 800,000 RMB. 2012-2014.
2. A Grant from National Natural Science Foundation of China (grant no.81071421), 360,000 RMB. 2011-2013.
3. A Grant from Natural Science Foundation of the Jiangsu Province (grant no. BK2007705 and 2009055), 400,000 RMB. 2010-2013.
4. A Grant from the Sci-Tech Innovation Team and Talents of Jiangsu University (grant no.2008-018-02). 1,500,000RMB. 2009-2013.
5. A Grant from Jiangsu Province’s Outstanding Medical Academic Leader Program grant no. LJ2011147. 1,500,000RMB. 2011-2015.
6. A Grant from Foundation of the Jiangsu Province for transfer of scientific and technological achievements (Grant no. BA2009124), 800,000 RMB. 2010-2013.

1.Second Nature Science Prize in Chinese Universities, The National Ministry of Education, 2008. Rank 1.
2.Second Prize of Science and Technology Progress in Jiangsu Province. 2006. Rank3.
3.Third Prize of Science and Technology Progress in Jiangsu Province. 2008. Rank 1.
4.Third Prize of Science and Technology Progress in Chinese Medical Association. 2006. Rank 3.
5.Third Prize of Science and Technology Progress in Jiangsu Province. 2004. Rank 1.

Publications
1. Xu W(Corresponding Author), Zhang X, Qian H, Zhu W, Sun X, Hu J, Zhou H, Chen Y. Mesenchymal stem cells from adult human bone marrow differentiate into a cardiomyocyte phenotype in vitro. Exp Bio Med, 2004, 229: 623-631.
2. Xu W(Corresponding Author), Qian H, Zhu W, Chen Y, Shao Q, Sun X, Hu J, Han C, Zhang X. A novel tumor cell line cloned from mutated human embryonic bone marrow mesenchymal stem cells. Oncol Rep, 2004, 12: 501-508.
3. Xu X, Qian H, Zhu W, Zhang X, Xu W(Corresponding Author). Isolation of cancer stem cells from transformed human mesenchymal stem cell line F6. J Mol Med, 2010, 88(11): 1181-1190.
4. Zhang X, Xu W (Corresponding Author), Qian H,etal. Mesenchymal stem cells modified to express lentivirus-TNFalpha- Tumstatin inhibit the growth of prostate cancer. J Cell Mol Med, 2011, 15(2): 433-444.
5. Zhu W, Huang L, Li Y, Qian H, Shan X, Yan Y, Mao F, Wu X, Xu W(Corresponding Author). Mesenchymal stem cell-secreted soluble signaling molecules potentiate tumor growth. Cell Cycle, 2011 Sep 15;10(18). [Epub ahead of print]
6. Chen Y, Qian H, Zhu W, Zhang X, Yan Y, Ye S, Peng X, Li W, Xu W(Corresponding Author). Hepatocyte growth factor modification promotes the amelioration effects of human umbilical cord mesenchymal stem cells on rat acute kidney injury. Stem Cell Dev, 2011, 20(1):103-113.
7. Qian Q, Qian H, Li W, Xu Z, Sun L, Xu W(Corresponding Author). 5-Azacytidine induces cardiac differentiation of human umbilical cord derived mesenchymal stem cells by activating extracellular regulated kinase?ERK?. Stem Cells Dev, 2011 Jun 1 [Epub ahead of print].
8. Wang S, Lu R, Xu W(Corresponding Author), Xing G, Zhao X, Wang S, Zhang Y, Han F, Michael A. Induction or inhibition of cytochrome P450 2E1 modifies the acute toxicity of acrylonitrile in rats: biochemical evidence. Arch Toxicol, 2010, 84(6): 461-469.
9. Cao H, Xu W(Corresponding Author), Qian H, Zhu W, Yan Y, Zhou H, Zhang X, Xu X, Li J, Chen Z, Xu X. Mesenchymal stem cell-like cells derived from human gastric cancer. Cancer lett, 2009, 274(1):61-71.
10. Xing G, Lu R, Xu W(Corresponding Author), Wang S, Zhao X, Wang S, Zhang Y, Shrinivas K, Mahendra B. Curcumin pretreatment protects against acute acrylonitrile-induced oxidative damage in rats. Toxicology, 2010, 267(1-3): 140-146.
11. Zhou H, Xu W (Corresponding Author), Qian H. Circulating RNA as a novel tumor marker: An in vitro study of the origins and characteristics of extracellular RNA. Cancer lett, 2008, 259(1): 50-60.
12. Yan Y, Xu W (Corresponding Author), Qian H, Cao H. Mesenchymal stem cells from human umbilical cords ameliorate mouse hepatic injury in vivo. Liver Int, 2009, 29(3): 356-365.
13. Chen Z, Xu W(Corresponding Author), Qian H, Zhu W, Bu X, Wang S, Yan Y, Mao F, Gu H, Cao H, Xu X. Oct4, a novel marker for human gastric cancer. J Surg Oncol, 2009,99(7): 414-419.
14. Xu X, Zhang X, Wang S, Qian H, Zhu W, Xu W(Corresponding Author). Isolation and comparison of mesenchymal stem-like cells from human gastric cancer and adjacent non-cancerous tissues. J Cancer Res Clin Oncol, 2011,137(3):495-504.
15. Han C, Zhang X, Xu W (Corresponding Author) , Wang W, Qian H, Chen Y. Cloning of nucleostemin gene and study on its function in transforming human embryonic bone marrow mesenchymal stem cells into F6 tumor cells. Int J Mol Med, 2006, 16(2): 205-213.
16. Lin J, Qian J, Yao DM, Li Y, Yang J, Chen Q, Chai HY, Xiao GF, Xu W(Corresponding Author). Rapid and reliable detection of IDH1 R132 mutations in acute myeloid leukemia using high-resolution melting curve analysis. Clin Biochem, 2011, 44(10-11):779-783.
17. Mao F, Xu W(Corresponding Author), Qian H, Zhu W, Xu HX. Immuno-suppressive effects of mesenchymal stem cells in collagen-induced mouse arthritis. Inflamm Res, 2010, 59(3): 219-225.
18. Zhu W, Huang L, Xu X, Qian H, Xu W(Corresponding Author). Anti-proliferation effect of BMI-1 in U937 cells with siRNA. Int J Mol Med, 2010, 25(6):889-895.
19. Qian H, Yang H, Xu W(Corresponding Author), Yan Y, Chen Q, Zhu W, Cao H, Yin Q, Zhou H, Mao F, Chen Y. Bone marrow mesenchymal stem cells ameliorate rat acute renal failure by differentiatinon into renal tubular epithelial -like cells. Int J Mol Med, 2008, 22(3): 325-332.
20. Qiao C, Xu W(Corresponding Author), Qian H, Yin Q, Jiang R, Yan Y, Mao F, Yang H, Wang X, Chen Y. Human mesenchymal stem cells isolated from the umbilical cord. Cell Biol Int, 2008, 32(1): 8-15.
21. Sun X, Cai H, Qian H, Zhu W, Xu W(Corresponding Author). Mesenchymal stem cells isolated from human uterine cervix cancer tissues. Cell Biol Int?2010, 35(2):119-123.
22. Cao H, Qian H, Xu W(Corresponding Author), Zhu W, Zhang X, Chen Y, Wang M, Yan Y, Xie Y. Mesenchymal stem cells derived from human umbilical cord ameliorate ischemia/reperfusion-induced acute renal failure in rats. Biotechnol Lett, 2010, 32(5):725-732.
23. Jiang R, Xu W (Corresponding Author), Zhu W, Chen M, Qian H, Qiao C, Yang H, Wang X, Chen Y. Histological type of oncogenity and expression of cell cycle gene in tumor cells from human mesenchymal stem cells. Oncol Rep, 2006, 16(5):1021-1028.
24. Qian H, Zhang X, Xu W (Corresponding Author), Zhu W, Cao H, Chen Y, Xu X, Wang M, Xie Y, Sun J. Lentivirus-modified human umbilical cord mesenchymal stem cells maintain their pluripotency. Biotechnol Appl Biochem, 2010, 55(1): 53-62.
25. Yan Y, Xu W(Corresponding Author), Qian H, Zhu W, Mao F, Zhang X. Tumstatin45-132-TNF alpha suppresses tumor growth through anti-angiogenic effects and cytotoxicity. Biotechnol Appl Biochem, 2010, 56(3):119-127.
26. Zhu W, Xu W (Corresponding Author), Jiang R, Qian H, Chen Y. Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo. Exp Mol Pathol, 2006, 80(3): 267-274 .
27. Xu W(Corresponding Author), Zhou H, Qian H, Bu X,Chen D, Gu H, Zhu W, Yan Y, Mao F. Combination of circulating CXCR4 and Bmi-1 mRNA in plasma: A potential novel tumor marker for gastric cancer. Mol Med Rep, 2009, 2: 765-771.