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Shengjun Wang

Date of Birth

Research Area
autoimune diseases (such as rheumatoid arthritis and Hashimoto's thyroiditis) and tumor immunology

Primary Course

Professinal Education
Professor Shengjun Wang,Department of Immunology, Jiangsu University. He is a Ph.D. supervisor, and Academic leader of Qinglan Project of Jiangsu province.

Academic Introduction
His research has been focusing on autoimune diseases (such as rheumatoid arthritis and Hashimoto's thyroiditis) and tumor immunology. Studies in RA paients and animal model have aimed to examine the subset of CD4+T cells and its role in maintaining quality control and homeostasis in the immune system. They are also interested in studying the tumor therapy by biological response modifiers. As Principle Investigator, he has chaired and completed more than 10 national and provincial research projects sponsored by the National Natural Science Foundation and the Natural Science Foundation of Jiangsu Province, and won a number of provincial prizes for his academic achievements. He has published more than 100 academic papers in such prestigious periodicals as PNAS U S A, J Immunol, Cellular Immunology, Onkologie, Cancer Letter, etc. He has supervised more than 20 doctoral and master’s degree candidates.

Scientific Research Item and Achievement
Recent research topics
1. The role of CD4+ Th cells and regulatory T cells in autoimmune diseases.
2. The GITR/GITRL signaling pathway in autoimmune diseases.
3. Tumor therapy by biological response modifiers.

Publications
Selected publications in recent years
1 Jie Tian, Shengjun Wang (corresponding author), Jun Yan, Jie Ma, Bin Ma, Chaoyang Wu, Zhijun Jiao, Chaoming Mao, Jianguo Chen, Yingzhao Liu, Liwei Lu, Qixiang Shao, Huaxi Xu. Increased expression of mGITRL on D2SC/1 cells by particulate beta-glucan impairs the suppressive effect of CD4+CD25+ regulatory T cells and enhances the effector T cell proliferation. Cellular Immunology, 2011;270(2):183-7.
2 Ma J, Wang S (corresponding author), Ma B, Mao C, Tong J, Yang M, Wu C, Jiao Z, Lu L, Xu H. Dendritic cells engineered to express GITRL enhance therapeutic immunity in murine Lewis lung carcinoma. Cancer Letter, 2011, 301(2):142-150
3 Dawei Cui, Shengjun Wang(corresponding author), Yu Chen, Jia Tong, Jie Ma, Li Tang, Xianzhi Yang, Ye Shi , Jie Tian, Liwei Lu, Huaxi Xu. An Isoleucine Zipper Motif Enhances Costimulation of Human Soluble Trimeric GITR ligand. Cell Mol Immunol, 2010,7(4) 316-322
4 Lam QL, Wang S, Ko OK, Kincade PW, Lu L. Leptin signaling maintains B cell homeostasis via induction of Bcl-2 and Cyclin D1. PNAS U S A, 2010,107(31):13812-13817
5 Yang M, Sun L, Wang S, Ko KH, Xu H, Zheng BJ, Cao X, Lu L Novel Function of B Cell-Activating Factor in the Induction of IL-10–Producing Regulatory B Cells. J Immunol, 2010, 184(7):3321-5
6 Yang P, Qiu G, Wang S(corresponding author), Su Z, Chen J, Wang S, Kong F, Lu L, Ezaki T, Xu H. The mutations of Th1 cell-specific T-box transcription factor may be associated with a predominant Th2 phenotype in gastric cancers. Int J Immunogenet. 2010, 37(2):111-115
7 Shi Y, Wang H, Su Z, Chen J, Xue Y, Wang S (corresponding author), Xue Y, He Z, Yang H, Zhou C, Kong F, Liu Y, Yang P, Lu L, Shao Q, Huang X, Xu H.Differentiation Imbalance of Th1/Th17 in Peripheral Blood Mononuclear Cells Might Contribute to Pathogenesis of HT. Scand J Immunol, 2010?72(3)?250-255
8 Chaoming Mao, Shengjun Wang(corresponding author), Qian Jiang , Jia Tong , Jie Ma, Min Yang , Xiaopeng Xu , Gufeng Qiu, Qixiang Shao, Long Li , Huaxi Xu. Increased CD4+CD25+FOXP3+ Regulatory T Cells in Cancer Patients from Conversion of CD4+CD25- T Cells through Tumor-derived Factors. Onkologie, 2008; 31(5).
9 Wang SJ (corresponding author), Xu HX, Wang YZ, Ma J, Mao CM, Shao QX, Ma B, Xu WR, Yang SL. Regulatory T cells induced by rAAV carrying the forkhead box P3 gene prevent autoimmune thyroiditis in mice. International Journal of Molecular Medicine, 2006; 18(6): 1193-1200
10 Lo CK, Lam QL, Sun L, Wang S, Ko KH, Xu H, Wu CY, Zheng BJ, Lu L. Natural killer cell degeneration exacerbates experimental arthritis in mice via enhanced interleukin-17 production. Arthritis Rheum. 2008;58(9):2700-11