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王梅

江苏大学医学院,医学博士,副教授,硕士生导师

教育经历:

2007/9 - 2012/6,江苏大学,临床检验诊断学专业,研究生,医学博士

2002/9 - 2007/7,江苏大学,医学检验专业,本科,医学学士

工作经历:

2015/7 -至今,江苏大学,临床检验与输血学教研室,副教授,硕士生导师

2014/1 - 2015/6,江苏大学,临床检验与输血学教研室,讲师,硕士生导师

2012/6 - 2013/12,江苏大学,临床检验与输血学教研室,讲师

主持或参加科研项目及人才计划项目情况:

主持科研项目

1. 国家自然基金面上项目,81772641,区域淋巴结转移胃癌exosome重塑骨髓MSC作用及其分子机制,2018/01-2021/12,  58    

2. 中国博士后科学基金面上项目,2017M611740,骨髓MSC促淋巴结转移胃癌恶化作用及其分子机制,2017/05-2018/11,  5  

3. 江苏省博士后基金,1701027A,淋巴结转移胃癌exosome重塑骨髓MSC促胃癌作用及机制,2017/10-2019/05   6                

4. 国家自然基金青年基金,81302119,胃癌MSC 源性miRNAs 再编程骨髓MSC 作用及机制研究,2014/01-2016/12  23  

5. 江苏省自然科学基金,BK20130540microRNA再编程骨髓间质干细胞转分化及机制研究,2013/06-2016/0720      

6.  江苏省普通高校自然科学研究项目,13KJB320001microRNA 调控骨髓MSC向胃癌MSC转分化及机制研究,2013/08-2015/123.2    

7.  江苏大学“青年骨干教师培养工程”青年学术带头人 2014/01-2017/12 6

参与科研项目

1. 国家自然基金面上项目,81472334,胃癌MSC源性细胞因子调节Th17/ Treg细胞分化作用机制及其临床应用,2015/01-2018/1270     排名3

2. 国家自然基金面上项目,81071421GC-MSC和癌组织来源的MicroRNAs

在胃癌诊治中的作用,2011/01-2013/1236    排名2

3. 江苏省科技厅临床医学科技专项,BL2012055,癌相关间质干细胞源性miRNA分析技术在胃癌分子诊断中的应用,2012/01-2015/12100  排名2

发表学术论文情况

发表SCI论文35篇,其中第一作者、共同第一作者和通讯作者SCI论文12篇,代表性论文列表如下:

1. Wang M, Yang F, Qiu R, Zhu M, Zhang H, Xu W, Shen B, Zhu W. The role of mmu-miR-155-5p-NF-κB signaling in the education of bone marrow-derived mesenchymal stem cells by gastric cancer cells, Cancer Med, 2018 Feb 14. doi: 10.1002/cam4.1355 第一作者/通讯作者 (SCI  IF:3.362 )  

2. Wang M, Chen B, Sun XX, Zhao XD, Zhao YY, Sun L, Xu CG, Shen B, Su ZL, Xu WR, Zhu W. Gastric cancer tissue-derived mesenchymal stem cells impact peripheral blood mononuclear cells via disruption of Treg/Th17 balance to promote gastric cancer progression, Exp Cell Res, 2017, 361(1):19-29第一作者(SCI  IF:3.546

3. Huang  F, Wang D, Yao Y, Wang M. PDGF signaling in cancer progression, Int J Clin Exp Med, 2017, 10 (7) :9918-9929 通讯作者 SCI  IF:1.069

4. Zhu M, Wang M, Yang F, Tian Y, Cai J, Yang H, Fu H, Mao F, Zhu W, Qian H, Xu W. miR-155-5p inhibition promotes the transition of bone marrow mesenchymal stem cells to gastric cancer tissue derived MSC-like cells via NF-κB p65 activation, Oncotarget, 2016, 7(13):16567-16580  共同第一作者/通讯作者(SCI  IF:5.165

5. Cai J, Wang M, Zhu M, Zhang Q, Zhang X, Yan Y, Qian H, Xu W. N-methyl-N-nitro-N'-nitrosoguanidine induces the expression of CCR2 in human gastric epithelial cells promoting CCL2-mediated migration, Mol Med Rep, 2016, 13(2):1083-1090共同第一作者(SCI  IF:1.692  

6. Wang M, Cai J, Huang F, Zhu M, Zhang Q, Yang T, Zhang X, Qian H1, Xu W. Pre-treatment of human umbilical cord-derived mesenchymal stem cells with interleukin-6 abolishes their growth-promoting effect on gastric cancer cells, Int J Mol Med, 2015,35(2):367-375第一作者(SCI IF:2.341

7. Zhang B, Wang M, Gong A, Zhang X, Wu X, Zhu Y, Shi H, Wu L, Zhu W, Qian H, Xu W. HucMSC-exosome mediated-Wnt4 signaling is required for cutaneous wound healing, Stem Cells, 2015, 33(7):2158-2168 共同第一作者 SCI  IF:5.599    

8. Wang M, Zhao C, Shi H, Zhang B, Zhang L, Zhang X, Wang S, Wu X, Yang T, Huang F, Cai J, Zhu Q, Zhu W, Qian H, Xu W. Deregulated microRNAs in gastric cancer tissue-derived mesenchymal stem cells: novel biomarkers and a mechanism for gastric cancer, Br J Cancer, 2014, 110(5):1199-1210 第一作者 SCI检索 IF: 6.176高被引用论文

9. Huang F, Wang M, Yang T, Cai J, Zhang Q, Sun Z, Wu X, Zhang X, Zhu W, Qian H, Xu W. Gastric cancer-derived MSC-secreted PDGF-DD promotes gastric cancer progression, J Cancer Res Clin Oncol, 2014,140(11):1835-1848 共同第一作者 SCI  IF: 3.503

10. Zhang Q, Wang M, Huang F, Yang T, Cai J, Zhang X, Zhu W, Qian H, Xu W. H. pylori infection-induced MSC differentiation into CAFs promotes epithelial-mesenchymal transition in gastric epithelial cells, Int J Mol Med, 2013, 32(6): 1465-1473 共同第一作者 SCI  IF:2.341

11. Wang M, Gu H, Qian H, Zhu W, Zhao C, Zhang X, Tao Y, Zhang L, Xu W. miR-17-5p/20a are important markers for gastric cancer and murine double minute 2 participates in their functional regulation, Eur J Cancer, 2013, 49(8):2010-2021 第一作者 SCI  IF: 6.029

12. Wang M, Gu H, Wang S, Qian H, Zhu W, Zhang L, Zhao C, Tao Y, Xu W. Circulating miR-17-5p and miR-20a: molecular markers for gastric cancer, Mol Med Rep, 2012, 5(6):1514-1520 第一作者 SCI  IF:1.692

13. Xu R, Zhao X, Zhao Y, Chen B, Sun L, Xu C, Shen B, Wang M, Xu W, Zhu W. Enhanced gastric cancer growth potential of mesenchymal stem cells derived from gastric cancer tissues educated by CD4+ T cells, Cell Prolif, 2017 Oct 22. doi: 10.1111/cpr.12399. SCI  IF:4.111

14. Qian H, Ding X, Zhang J, Mao F, Sun Z, Jia H, Yin L, Wang M, Zhang X, Zhang B, Yan Y, Zhu W, Xu W. Cancer stemness and metastatic potential of the novel tumor cell line K3: an inner mutated cell of bone marrow-derived mesenchymal stem cells. Oncotarget, 2017, 8(24):39522-39533 SCI  IF: 5.165

15. Zhu Y, Yu J, Yin L, Zhou Y, Sun Z, Jia H, Tao Y, Liu W, Zhang B, Zhang J, Wang M, Zhang X, Yan Y, Xue J, Gu H, Mao F, Xu W, Qian H. MicroRNA-146b, a Sensitive Indicator of Mesenchymal Stem Cell Repair of Acute Renal Injury, Stem Cells Transl Med, 2016, 5(10):1406-1415 SCI  IF: 4.247

16. Zhang B, Shi Y, Gong A, Pan Z, Shi H, Yang H, Fu H, Yan Y, Zhang X, Wang M, Zhu W, Qian H, Xu W. HucMSC Exosome-Delivered 14-3-3ζ Orchestrates Self-Control of the Wnt Response via Modulation of YAP During Cutaneous Regeneration, Stem Cells, 2016, 34(10):2485-2500 SCI  IF:5.599

17. Mao F, Wang M, Wang J, Xu WR. The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer, Inflamm Res, 2015,64(9):661-669 SCI  IF: 2.659

18. Xu XJ, Gao S, Wang M, Qian H, Gu GY, Zhang K, Xu WR.Methylation status of the FHIT gene in the transformed human mesenchymal F6 stem cell line, Oncol Lett, 2015, 9(6):2661-2666 SCI  IF: 1.39

19. Ji R, Zhang B, Zhang X, Xue J, Yuan X, Yan Y, Wang M, Zhu W, Qian H, Xu W. Exosomes derived from human mesenchymal stem cells confer drug resistance in gastric cancer, Cell Cycle, 2015, 14(15):2473-2483 SCI  IF: 3.53

20. Zhu Q, Zhang X, Zhang L, Li W, Wu H, Yuan X, Mao F, Wang M, Zhu W, Qian H, Xu W. The IL-6-STAT3 axis mediates a reciprocal crosstalk between cancer-derived mesenchymal stem cells and neutrophils to synergistically prompt gastric cancer progression, Cell Death Dis, 2014, 5:e1295 SCI  IF: 5.965

21. Yang T, Zhang X, Wang M, Zhang J, Huang F, Cai J, Zhang Q, Mao F, Zhu W, Qian H, Xu W. Activation of mesenchymal stem cells by macrophages prompts human gastric cancer growth through NF-κB pathway, PLoS One, 2014, 9(5):e97569 SCI  IF: 2.806

22. Zhang L, Xu Z, Xu X, Zhang B, Wu H, Wang M, Zhang X, Yang T, Cai J, Yan Y, Mao F, Zhu W, Shao Q, Qian H, Xu W.SALL4, a novel marker for human gastric carcinogenesis and metastasis, Oncogene, 2014,33(48):5491-5500 SCI  IF: 7.519

23. Li W, Zhang Q, Wang M, Wu H, Mao F, Zhang B, Ji R, Gao S, Sun Z, Zhu W, Qian H, Chen Y, Xu W. Macrophages are involved in the protective role of human umbilical cord-derived stromal cells in renal ischemia-reperfusion injury, Stem Cell Res, 2013, 10(3):405-416  SCI  IF: 3.892

24. Li T, Yan Y, Wang B, Qian H, Zhang X, Shen L, Wang M, Zhou Y, Zhu W, Li W, Xu W. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate liver fibrosis, Stem Cells Dev, 2013, 22(6):845-854 SCI  IF: 3.562

25. Zhu W, Huang L, Li Y, Zhang X, Gu J, Yan Y, Xu X, Wang M, Qian H, Xu W. Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo, Cancer Lett, 2012, 315(1):28-37 SCI  IF:6.375

26. Xu X, Qian H, Zhu W, Zhang X, Yan Y, Wang M, Xu W. Isolation of cancer stem cells from transformed human mesenchymal stem cell line F6, J Mol Med (Berl), 2010, 88(11):1181-1190 SCI  IF: 4.686

27. Xu X, Zhang X, Wang S, Qian H, Zhu W, Cao H, Wang M, Chen Y, Xu W. Isolation and comparison of mesenchymal stem-like cells from human gastric cancer and adjacent non-cancerous tissues, J Cancer Res Clin Oncol, 2011, 137(3):495-504 SCI  IF:3.503

获奖情况:

1. 2016年获镇江市优秀科技论文一等奖

2. 2016年获镇江市优秀科技论文三等奖

3. 2015年获临床应用生物化学与分子生物学分会2015年学术年会青年学者学术论文二等奖

4. 2014年获江苏大学第七届教师教学竞赛新教师组三等奖

5. 2014年获江苏大学“青年骨干教师培养工程”青年学术带头人培育人选称号

6. 2013年获镇江市优秀科技论文一等奖