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杜凤移

杜凤移

副教授 硕士生导师

江苏省333工程”中青年学术技术带头人

江苏省‘六大人才高峰’高层次人才

江苏省青年医学重点人才

江苏大学青年学术带头人

江苏大学新长征突击手

   biodfy@ujs.edu.cn

简介                                                                                

副教授,硕士研究生导师,耶鲁大学访问副教授。入选江苏省六大人才高峰, 江苏省‘333工程’青年学术技术带头人,江苏省青年医学重点人才,江苏大学青年学术带头人,江苏大学新长征突击手,英国皇家化学会会员,中国免疫学会会员,江苏省免疫学会青年工作委员会委员。主要从事纳米医学与肿瘤免疫诊疗领域的研究工作。围绕高灵敏度、高特异性多功能医学影像探针的可控设计、构建及生物相容性评价等方面开展研究工作,制备了一系列基于碳基质纳米颗粒的活细胞荧光成像与示踪标记、体内MRI肿瘤早期检测的新型探针,为临床个体化诊疗提供有力帮助。作为项目负责人主持国家自然科学基金青年基金项目、中国博士后基金面上项目和博士后特别资助项目各一项等省部级以上项目课题7项。在生物医用材料领域Biomaterials, JBN, JCR, Nanotechnology等国际权威期刊上共发表论文30余篇,其中以第一作者或通讯作者发表SCI论文14篇,影响因子大于8的论文2篇,单篇论文他引最高90次;授权国家科技发明专利1项。

教育及工作经历                                                                                

2016/11至今 耶鲁大学医学院 访问副教授

2015/05至今 江苏大学医学院 副教授

2014/09至今 江苏大学医学院 硕士生导师

2013/09至今 江苏大学食品学院 博士后

2012/042015/05  江苏大学医学院 讲师

2008/092011/12  南开大学 生命科学学院 生物材料 博士

2005/092008/07  四川师范大学 生命科学学院 细胞生物学 硕士

2001/092005/07  长春师范大学 生命科学学院 生命科学 学士

                 

发表论文                                                                                

2018

24. Shenqiang Zou, Xiaofang Zhu, Lirong Zhang, Fan Guo, Miaomiao Zhang, Youwen Tan, Aihua Gong, Zhengzou Fang, Huixiang Ju, Fengyi Du,Biomineralization-Inspired Synthesis of Cerium-doped Carbonaceous Nanoparticles for Highly Hydroxyl Radical Scavenging Activity. Nanoscale Research Letters. 2018. (已正式接收)

25. Yu X, Gou X, Wu P, Han L, Tian D, Du F, Chen Z, Liu F, Deng G, Chen AT, Ma C, Liu J, Hashmi SM, Guo X, Wang X, Zhao H, Liu X, Zhu X, Sheth K, Chen Q, Fan L, Zhou J.Activatable Protein Nanoparticles for Targeted Delivery of Therapeutic Peptides. Adv Mater. 2018 Feb;30(7). doi: 10.1002/adma.201705383. Epub 2018 Jan 8.

2017

23. Zhengzou Fang, Rong Jiang,Lirong Zhang, Yunchao Wu, Xuefen Zhao, Lulu Zhao, Jiangang Li, Shengqiang Zou, Miaomiao Zhang, Fengyi Du*. In situ fabrication of radiopaque microcapsules for oral delivery and real-time gastrointestinal tracking of Bifidobacterium. Int J Nanomedicine. 2017; (通讯作者,已接受)

22. Du F, Lou J, Jiang R, Fang Z, Zhao X, Niu Y, Zou S, Zhang M, Gong A, Wu C. Hyaluronic acid-functionalized bismuth oxide nanoparticles for computed tomography imaging-guided radiotherapy of tumor. Int J Nanomedicine. 2017; 12: 5973-5992.

21. M. Zhang, X. Zhao, Z. Fang, Y. Niu, J. Lou, Y. Wu, S. Zou, S. Xia, M. Sun, F. Du*, Fabrication of HA/PEI-functionalized carbon dots for tumor targeting, intracellular imaging and gene delivery. RSC Adv., 2017. 7. 3369–3375. (通讯作者)

20 Fengyi Du, Lirong Zhang, Li Zhang, Miaomiao Zhang, Aihua Gong, Youwen Tan, Jiawen Miao, Yuhua Gong, Chaoyang Wu, Huixiang Ju, Shengqiang Zou*. Engineered gadolinium-doped carbon dots for magnetic resonance imaging-guided radiotherapy of tumors. Biomaterials, 2017. 121.109-120.

2016

19 Li Zhang, Tian Zhao, Huixiang Ju, Miaomiao Zhang, Lirong Zhang, Xuemei Wang, Aihua Gong, Jie Jin, Yuhua Gong, Shengqiang Zou, Fengyi Du*, Hyaluronic acid-functionalized gadolinium oxide nanoparticles for magnetic resonance imaging-guided radiotherapy of tumors. International journal of nanomedicine. 2016(Accepted, Corresponding author)

18 M. Zhang, Z. Fang, X. Zhao, Y. Niu, J. Lou, L. Zhao, Y. Wu, S. Zou, Q. Shao, F. Du*. Hyaluronic acid functionalized Nitrogen-doped carbon quantum dots for targeted specific bioimaging. RSC Adv., 2016, 6, 104979-104984. (Corresponding author)

17. Xu M, Bian S, Li J, He J, Chen H, Ge L, Jiao Z, Zhang Y, Peng W, Du F, Mo Y, Gong A*. MeCP2 suppresses LIN28A expression via binding to its methylated-CpG islands in pancreatic cancer cells. Oncotarget. 2016 Feb 19. doi: 10.18632/oncotarget. 7507. 

16. 16Wang J, Zhuo Y, Yin L, Wang H, Jiang Y, Liu X, Zhang M, Du F, Xia S, Shao Q*. Doxycycline Protects Thymic Epithelial Cells from Mitomycin C-Mediated Apoptosis In Vitro via Trx2-NF-x03BA;B-Bcl-2/Bax Axis. Cell Physiol Biochem. 2016; 38 (2):449-60.

2015

15. Peng W, DU T, Zhang Z, Du F, Jin J, Gong A*. Knockdown of autophagy-related gene LC3 enhances the sensitivity of HepG2 cells to epirubicin. Exp Ther Med. 2015. 9(4):1271-1276.

14. Fengyi Du, Jianan Li, Miaomiao Zhang, Zhou Zhou, Jing Yuan, Jun Wang, Li Zhang, Xia Liu, Genbao Shao, Jie Jin, Sheng Xia, Shiming Yang, Aihua Gong, Wenrong Xu, Qixiang Shao*. Multicolor nitrogen-doped carbon dots for live cell imaging. Journal of biomedical nanotechnology. 2015. 11, 780-788.

13. Miaomiao Zhang, Huixiang Ju, Li Zhang, Mingzhong Sun, Zhongwei Zhou, Zhenyu Dai, Lirong Zhang, Aihua Gong, Fengyi Du*. Engineering iodine-doped carbon dots as dual-modal probes for fluorescence and X-ray CT imaging. International journal of nanomedicine. 2015. 10:6943-53. (通讯作者)

2014

12. Fengyi Du, Xiaofeng Li, Miaomiao Zhang, Jianan Li, Xinyi Jiang , Zhou Zhou, Jing Yuan, Zhang Li , Hua Ye, Qixiang Shao, Ming Zhou, Aihua Gong*. Economical and green synthesis of bagasse-derived fluorescent carbon dots for biomedical applications. Nanotechnology. 2014, 25(31): 315702.

11. Fengyi Du, Xin Jin, Junhui Chen, Ye Hua, Mulan Cao, Lirong Zhang, Jianan Li, Li Zhang, Jie Jin, Chaoyang Wu, Aihua Gong, Wenrong Xu, Qixiang Shao, Miaomiao Zhang*, Nitrogen-doped carbon dots as multifunctional fluorescent probes. Journal of Nanoparticle Research. 2014, 16:2720.

10. Fengyi Du, Jing Yuan, Miaomiao Zhang, Jianan Li, Zhou zhou, Zhang Li, Mulan Cao, Wanxin Peng, Junhui Chen, Aihua Gong, Wenrong Xu, Qixiang Shao*. Facile Synthesis of Biocompatible Nitrogen-doped Carbon Dots for Bioimaging. RSC advance. 2014, 4 (71), 37536-37541.  

9. Liu X, Zhao Q, Peng X, Xia S, Shen W, Zong Y, Cheng J, Wu W, Zhang M, Fengyi Du, Xu W, Qian H, Shao Q*. PTD-mediated intracellular delivery of mutant NFAT minimum DNA binding domain inhibited the proliferation of T cells. Int Immunopharmacol. 2014. 19(1):110-8.

8. Jiang X, Xin H, Gu J, Fengyi Du, Feng C, Xie Y, Fang X*. Enhanced Antitumor Efficacy by d-Glucosamine-Functionalized and Paclitaxel-Loaded Poly(Ethylene Glycol)–Co–Poly (Trimethylene Carbonate) Polymer Nanoparticles. J Pharm Sci. 2014. 11. 

7. Jiang Xinyi, Xin Hongliang, Ren Qiuyue, Gu Jijin, Zhu Lingjun, Du Fengyi, Feng Chunlai, Xie, Yike, Sha Xianyi, Fang Xiaoling*. Nanoparticles of 2-deoxy-D- glucose functionalized poly(ethylene glycol)–co–poly (trimethylene carbonate) for dual- targeted drug delivery in glioma treatment. Biomaterials, 2014. 35 (1):518-529.

2013

6. Long L, Zhou L, Wang L, Meng S, Gong A, Fengyi Du, Zhang C.A*. Coumarin-based fluorescent probe for biological thiols and its application for living cell imaging. Org Biomol Chem. 2013. 21;11(47):8214-20.

5. Long Lingliang, Zhou Liping, Wang Lin, Meng Suci, Gong Aihua, Fengyi Du, Zhang Chi*. A highly selective and sensitive fluorescence ratiometric probe for cyanide and its application for the detection of cyanide in natural water and biological samples. Analytical Methods. 2013; 5:(23): 6605-6610.

2012

4. Yu M, Fengyi Du, Ise H, Zhao W, Zhang Y, Yu Y, Yao F, Yang J, Akaike T*, Preparation and characterization of a VEGF-Fc fusion protein matrix for enhancing HUVEC growth. Biotechnol Lett, 2012. 34(9):1765-71. (The first co-author)

3. Fengyi Du, Hao Wang, Wei Zhao, Dong Li, Deling Kong, Yun Yang*, Yuanyuan Zhang, Gradient nanofibrous chitosan/poly ɛ-caprolactone scaffolds as extracellular microenvironments for vascular tissue engineering, Biomaterials, 2012. 33(3), 762-770,

2011

2. Fengyi Du, Wei zhao, Miaomiao Zhang, Hongli Mao, Deling Kong, Jun Yang*, The synergistic effect of aligned nanofiber and hyaluronic acid coating on endothelial cell behavior for vascular tissue engineering, Journal of Nanoscience and Nanotechnology, 2011. 11(8), 6718-6725.

2009

1. Niu G, Fengyi Du, Song L, Zhang H, Yang Y, Cao H, Zheng Y, Yang Z, Wang G, Yang H, Zhu S*. Synthesis and characterization of reactive poloxamer 407s for biomedical applications, J Control Releas, 2009. 138 (1):49-56. (The first co-author)

                                                                     

1. 国家自然基金青年项目。多功能聚胺基碳量子点的制备及其应用于siRNA基因转运和示踪成像的研究。起止时间:2014-012016-12金额:24万。项目批准号:81301316主持人

2. 中国博士后科学基金特别资助项目。MRI-荧光钆掺杂型碳量子点在肝癌早期诊疗中的应用。起止时间:2014-012016-12金额:15万。项目批准号:2014T70486主持人

3. 中国博士后科学基金面上项目一等。多功能聚氨基碳量子点的制备及其生物医学的应用研究金额:8万(一等)。起止时间:2014-012015-12项目批准号:2013M540425主持人

4. 江苏大学高级专业人才科研启动基金。VEGF控释梯度纳米纤维支架在血管组织工程中的应用研究。2013-012014-12金额:5万。项目批准号:13JDG022主持人

5. 江苏省卫生计生委‘科教强卫工程’青年医学重点人才。构建铋掺杂型碳纳米颗粒应用于多模态影像引导下的肿瘤放射治疗. 项目批准号:QNRC2016444. 金额: 30. 2016/01/01 2020/12/31主持人

6. 江苏省教育厅333高层次人才培养工程” 科研项目资助计划。基于CBT-Cys 点击化学酶促聚合型多功能碳量子点的构建及应用 2016/112018/11. 项目批准号:BRA2017145. 金额:3. 主持人

7. 江苏省委组织部“六大人才高峰”高层次人才项目。诊疗型碳量子点的构建及其在多模态影像引导放射治疗中的应用研究 2017/92019/9. 项目批准号:WSN-281.金额:4. 主持人

                                                                                                             

1. 发明人:杜凤移,张丽,张礼荣,张苗苗,华晔,龚爱华,邵启祥。发明名称:一种基于碳量子点的荧光-MRI双模态影像探针的制备方法及其应用。授权专利号ZL 2014 1 0393974. 0

2. 发明人:杜凤移居会祥,孙明忠,张苗苗,张丽,房正邹,赵雪芬。发明名称:一种荧光-CT双模态影像探针及其制备方法授权专利号: ZL 2015 1 0062498.9

3. 发明人: 杜凤移,张苗苗,邵启祥,夏圣,许化溪,许文荣,钱晖,刘霞。 发明名称:种高荧光性能碳量子点的制备方法。申请号:CN201310168911

4. 发明人:张苗苗,杜凤移龚爱华,邵启祥,邵根宝,彭琬昕,金洁,吴卫疆,周洲,袁婧。发明名称:一种环保经济型荧光碳量子点的制备方法申请号:CN201310225051

5. 发明人:杨军,于美华,杜凤移发明名称: 一种内皮细胞生长因子融合蛋白及其在再生医学中的应用。申请号:CN201110202533

                                                                                   

1. 2010.05 荣获全国生物材料青年学者论坛优秀论文二等奖。

2. 2013.05 荣获江苏省发育生物学学会优秀墙报。

3. 2014.11 荣获中国博士后学术论坛优秀论文奖。

人才称号                                                                      

1. 2015.12 入选江苏大学青年学术带头人

2. 2016.05 入选江苏大学新长征突击手

3. 2016.08 入选江苏省333工程”中青年学术技术带头人

4. 2016.12 入选江苏省青年医学重点人才

5. 2017.09 入选江苏省‘六大人才高峰’高层次人才