医学院 ENGLISH 江苏大学首页

当前位置 首页 >> 师资队伍 >> 教师风采 >> 正文

生秀梅

出生日期:
1978年1月

所在单位及职称:
江苏大学医学院基础医学系生物化学教研室,医学博士,副教授,硕士生导师

受教育经历:
2006-2009,江苏大学基础医学与医学技术学院临床检验诊断学专业,获研究生学历,博士学位
2002-2005,华中师范大学生命科学院生物化学与分子生物学专业,获研究生学历,硕士学位
1995-1999,华中师范大学生命科学院生物化学专业,获本科学历,学士学位

工作经历:
2013.5-2014.5,美国德克萨斯大学MD安德森癌症中心,访问副教授
2012.8- 至今 江苏大学基础医学与医学技术学院,硕士生导师    
2011.8- 至今 江苏大学基础医学与医学技术学院,副教授
2005.8-2011.7,江苏大学基础医学与医学技术学院,讲师
2003.9-2005.6,华中师范大学研究生学报,兼职编辑
2003.9-2005.6,美中医学评论,兼职编辑
1999.8-2005.7,江苏大学基础医学与医学技术学院,助教

主讲课程
本科生教学:《生物化学与分子生物学》,
留学生全英文教学:《Biochemistry and molecular biology》
研究生教学:《高级生物化学》

研究领域
细菌的基因表达调控及其致病机制研究;肿瘤发生发展过程中P44基因的分子调控机制研究;抑癌基因GLIPR1抑制肺癌细胞发生发展机制及其临床应用的研究。

科研项目
1.国家博士后基金面上项目, 2015M571702、Mig-14参与伤寒沙门菌致病机制研究,在研,主持; 
2.国家自然科学基金面上项目,81371780、长链反义RNA调控伤寒沙门菌毒力机制研究,在研,参与; 
3.国家青年自然科学基金项目,31000046、Mig-14参与伤寒沙门菌耐多粘菌素B机制研究,已结题,主持;
4.江苏大学高级人才启动基金项目,11JD063、Mig-14参与伤寒沙门菌耐药机制研究,在研,主持;
5.江苏省教育厅项目,08KJD310012、、高渗应激下PhoP与OmpR交叉调节伤寒沙门菌基因表达,已结题,主持。

科研成果
1. Xiumei Sheng, Xinxiang Huang, Linxiang Mao, et al. Preparation of salmonella enteric servor Typhi genomic DNA microarrays for gene expression profiling analysis. Prog. Biochem. Biophy, 2009, 获镇江市优秀科技论文三等奖;
2. 伤寒沙门菌基因组DNA芯片的制备与基因表达谱分析应用研究,2009年,通过教育部鉴定,排名第二;
3. 伤寒沙门菌基因组DNA芯片的制备与基因表达谱分析应用,获镇江市科技进步三等奖,排名第二。

国家专利
生秀梅,黄新祥,徐顺高等. 伤寒沙门菌DNA芯片转录表达谱用基因组特异引物. 200910031165.4 已授权

近年来部分已发表论文:
1.Sheng XM, Bowen N, Wang ZX. GLI pathogenesis-related 1 functions as a tumor-suppressor in lung cancer. Mol Cancer. 2016, 15(1):25. (SCI收录)
2.Sheng XM, Zhang H, Xia QF, et al. Mig-14 plays an important role in influencing gene expression of salmonella enterica serovar Typhi, which contributes to cell invasion under hyperosmotic conditions. Research in Microbiology. 2013, 903~912. (SCI收录)
3.Sheng XM, Xu SG, Lu RY, et al. Design of a comprehensive biochemistry and molecular biology experiment: Phase variation caused by recombinational regulation of bacterial gene expression. Biochemistry and molecular biology education. 2014, 224~229. (SCI收录)
4.Sheng XM, Huang XX, Mao LX, et al. Preparation of salmonella enteric servor Typhi genomic DNA microarrays for gene expression profiling analysis. Prog. Biochem. Biophy, 2009, 36(2): 206~212(SCI收录)
5.Sheng XM, Huang XX, Li JH, et al. Regulation of sulphur assimilation pathways in salmonella enterica serovar Typhi upon up-shift high osmotic treatment: the role of UhpA revealed through transcriptome profiling. Curr Microbiol. 2009, 59: 628~635. (SCI收录)
6.Sheng XM, Xiong L, Wu ZB, et al. Toxicity of Cypermethrin to Daphnia Magna HB,Journal of environmental sciences. 2004, 16(5): 770~771.(SCI收录)
7.生秀梅, Wang ZX. pGL3-4×PRE-E4-luc报告基因质粒的构建及在p44信号通路中的应用鉴定[J]. 华中师范大学:自然科学版. 2016, 50(1).
8.生秀梅,黄新祥,徐顺高,等. 伤寒沙门菌基因组DNA芯片基因表达谱分析技术的建立与优化[J]. 江苏大学学报:医学版. 2009, 19(4): 281~285.
9.生秀梅,徐顺高,黄新祥,等. OmpR与PhoP高渗应激下交叉调节伤寒沙门菌基因表达[J]. 华中师范大学:自然科学版. 2010, 44(4): 633~638.
10.生秀梅,徐顺高,黄新祥,等. 细菌小RNA的研究[J]. 生命的化学. 2010, 30(6): 815~820.
11.Sheng XM, Xiong L, et al. The Toxicity of Two Newly-synthesized Compounds on Scenedesmus obliquus kütz. Acta Hydrobiologica Sinica, 2006, 30(6): 676~679.
12.生秀梅,熊丽,唐红枫 ,等. 细胞色素P450作为生物标志物在毒理学上的应用[J]. 四川环境. 2005, 24(3): 74~78.
13.生秀梅. 如何推进医药院校生物化学课程互动式教学的实施[J]. 考试周刊. 2009, 8: 180~181.
14.张红,生秀梅,徐顺高,黄新祥,许化溪. 伤寒沙门菌Mig-14蛋白周质空间部分经密码子优化后的表达及多克隆抗体制备[J],华中师范大学学报(自然科学版). 2014,48(2): 246~250
15.张晓磊,生秀梅,张海方,徐顺高,黄新祥. H:Z66抗体应激后伤寒沙门菌fliG基因缺陷株与野生株基因表达的差异[J]. 江苏大学学报:医学版. 2012, 22(1): 9-13.
16.Zhang HF, Sheng XM, Xu SG, et al. Global transcriptional response of Salmonella enterica serovar Typhi to anti-z66 antiserum. FEMS Microbiol Lett. 2009, 298: 51~55. (SCI收录)
17.Du H, Sheng XM, Zhang HF, et al. RpoE may promote the expression of fljB:z66 in Salmonella enterica serovar Typhi under hyperosmotic stress by initiating the expression of fliA. Curr Microbiol. 2011, 62: 492~500. (SCI收录)
18.Xu SG, Zhang HF, Sheng XM, et al. Transcriptional expression of fljB:z66, a flagellin gene located on a novel linear plasmid of Salmonella enterica serovar Typhi under environmental stresses. New Microbiol. 2008, 31: 241~247. (SCI收录)
19.Xu SG, Xin Z, Sheng XM, Zhang HF, et al. Expression of fljB:z66 on a linear plasmid of Salmonella enterica serovar Typhi is dependent on FliA and FlhDC and regulated by OmpR. Braz J Microbiol. 2010, 41: 729~740
20.Zou X, Huang XX, Xu SG, Zhou LP, Sheng XM, Zhang HF, et al. Identification of a fljA gene on a linear plasmid as the repressor gene of fliC in Salmonella enterica serovar Typhi. Microbiol Immunol. 2009, 53: 191~197. (SCI收录)
21.Zhang HF, Du H, Ji XL, Ni B, Mao LX, Xu SG, Sheng XM, Xu HX, Huang XX, OmpR may regulate the putative YehU/YehT two-component system in Salmonella enterica serovar Typhi under hypotonic growth condition. Current microbiology, 2012, 64: 283~289
22.Wang M, Luo Z, Du H, Xu SG, Ni B, Zhang HF, Sheng XM, Xu HX, Huang XX. Molecular characterization of a functional type VI secretion system in Salmonella enterica serovar Typhi. Current microbiology, 2011, 63: 22~31.(SCI收录)
23.Dadzie I, Xu SG, Ni B, Zhang X, Zhang HF, Sheng XM, Huang XX. Identification and characterization of a cis-encoded antisense RNA associated with the replication process of Salmonella enterica serovar Typhi. PLos One, 2014, 8: e61308.
24.Dadzie I, Ni B, Gong MY, Ying Z, Zhang HF, Sheng XM, Xu SG, Huang XX. Identification and characterization of a cis antisense RNA of the parC gene encoding DNA topoisomerase IV of Salmonella enterica serovar Typhi. Res Microbiol. 2014, 165: 439-446.
25.Xiong L, Xie P, Sheng XM, et al. Toxicity of Cypermethrin on Growth, Pigments and SOD of Scenedesmus obliquus. Ecotoxicology and Environmental Safety. 2005, 60: 188~192.(SCI收录)
26.Xie XM, Li AP, Du H, Sheng XM, et al. Expression of tviA is repressed by Hfq in Salmonella enterica serovar Typhi at hyperosmotic stress. Microbial pathogenesis. 2010, 49(1-2): 54~57. (SCI收录) 
27.Zhang Q, Zhang Y, Zhang XL, Zhan LF, Zhao X, Xu SG, Sheng XM, Huang XX. The novel cis-encoded antisense RNA AsrC positively regulates the expression of rpoE-rseABC operon and thus enhances the motility of Salmonella enterica serovar Typhi. Front Microbiol. 2015, 17(6): 990. (SCI收录)
28.Gong MY, Xu SG, Jin Y, Zhang Y, Dadzie I, Zhang XL, Wang ZX, Zhu YX, Ni B,  Sheng XM, Huang XX. 5’-UTR of malS increases the invasive capacity of Salmonella enterica serovar Typhi by influencing the expression of bax. Future Microbiol. 2015, 10(6): 941-954. (SCI收录)