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研究领域:

1. 病毒感染性疾病的病毒宏基因组学诊断;

2. 新发病毒致病性研究;

3. 戊型肝炎病毒致病性研究;

个人简介:

19782月生,博士,副教授,硕士研究生导师,20095月毕业上海交通大学获生物医学工程博士学位; 201311月至201412月受国家留学基金(CSC)资助在美国加州大学旧金山分校检验医学系Delwart Eric教授实验室系统学习病毒宏基因组学诊断方法;美国微生物学会会员,江苏省微生物学会病毒专业委员会委员;2013年遴选为江苏大学青年骨干教师培养对象;Emerging Infectious Diseases, Journal of Virology等杂志审稿人

学术简介:

主要从事病毒感染临床诊断及病毒致病性研究;主持国家级课题2项,省部级课题5项;以第一作者或通讯作者发表SCI收录论文30余篇;获省级科技奖两项,市厅级奖项3项;

 

主持科研项目:

1、 国家重点研发计划子课题:2017YFC1200201,重要疫源病毒宏基因组学解析及新发病毒适应性研究;20177-20206月、137.7万、在研,主持人。

2、 江苏省重点研发计划:BE2017693, 未知新型病毒快速确认技术平台的建立及应用,20177-20206月,40万,在研,主持人。

3、 国家自然科学基金青年基金项目,31302107,宿主细胞内参与戊型肝炎病毒跨种间感染相关蛋白的筛选及鉴定,2014/01-2016/1225万,结题、主持人;

4、 中国博士后基金特别资助,2015T80503,大熊猫呼吸道及肠道病毒宏基因组学研究,2015/01-2016/1215万,结题、主持人;

5、 江苏省自然科学基金青年基金项目,BK201240744,宿主细胞内参与戊型肝炎病毒跨种间感染关键蛋白的筛选及鉴定,2013/07-2015/0620万,结题、主持人;

6、 教育部博士点基金-新教师类,20113227120008,我国新发基因III型戊肝病毒分子起源及种间传播可能性研究;起止年月:20121-201412月、4万,结题、主持;

7、 中国博士后基金面上项目,华东地区基因III型戊肝病毒分子起源及种间传播可能性研究;起止年月:20131-201512月、5万,主持

 

发表主要论文:

(一)第一作者论文:

1. Zhang W, Yang S, Shan T, Hou R, Liu Z, Li W, Guo L, Wang Y, Chen P, Wang X, Feng F, Wang H, Chen C, Shen Q, Zhou C, Hua X, Cui L, Deng X, Zhang Z, Qi D, Delwart E.Virome comparisons in wild-diseased and healthy captive giant pandas. Microbiome. 2017 Aug 7;5(1):90. 影响因子IF=8.49TOP期刊

2. Zhang W, He Y, Wang H, Shen Q, Cui L, Wang X, Shao S, Hua X. Hepatitis E Virus Genotype Diversity in Eastern China. Emerging infectious Diseases, 2010, 16,1630-1632.影响因子IF=3.1

3. Zhang W, Li L, Deng X, Blümel J, Nübling CM, Hunfeld A, Baylis SA, Delwart E. Viral nucleic acids in human plasma pools. Transfusion. 2016 Sep;56(9):2248-55. 影响因子IF=6.89TOP期刊

4. Zhang W, Li L, Deng X, Kapusinszky B, Delwart E. What's for dinner?viral metagenomics of US store bought beef, pork, and chicken. Virology. 2014 Nov;468-470:303-10. 影响因子IF=3.2

5. Zhang W, Li L, Deng X, Kapusinszky B, Pesavento PA, Delwart E. Faecal virome of cats in an animal shelter. J Gen Virol. 2014 Nov;95(Pt 11):2553-64.. 影响因子IF=3.5

6. Zhang W, Shen Q, Hua X, Cui L. Novel Hepatitis E Virus Genotype in Norway Rats, Germany . Emerging infectious Diseases, 2011, 17,1981-1982. 影响因子IF=6.18

7. Zhang W, Hua X, Shen Q, Yang Sg, Yin H, Cui L. Identification of Genotype 4 Hepatitis E Virus binding proteins on Swine Liver Cells. Virology Journal, 2011, 8: 512. 影响因子IF=2.3

8. Zhang W, Yang S, Shen Q, Ren L, Shan T, Wei J, Cui L, Hua X. Complete genome sequence of a novel porcine enterovirus strain in china. J Virol. 2012 Jun;86(12):7008-9.影响因子IF=5.2TOP期刊;

9. Zhang W, Yang SX, Ren LP, Shen Q, Xiu HF, Fan KZ, Kang YJ, Hua XG. Hepatitis E virus infection in central China reveals no evidence of cross-species transmission between human and swine in this area. PLoS One, 2009;4(12):e8156. 影响因子IF=4.35

10. Zhang W, Yang S, Shen Q, Liu J, Shan T, Huang F, Ning H, Kang Y, Yang Z, Cui L, Zhu J, Hua X. Isolation and characterization of a genotype 4 Hepatitis E virus strain from an infant in China. Virol J. 2009 16;6(1):24.影响因子IF=2.3

11. Zhang W, Shen Q, Mou J, Yang ZB, Yuan CL, Cui L, Zhu JG, Hua XG, Xu CM, Hu J Cross-species infection of hepatitis E virus in a zoo-like location, including birds. Epidemiol Infect. 2008;136(8):1020-1026. 影响因子IF=2.8

12. Zhang W, Shen Q, Mou J, Gong G, Yang Z, Cui L, Zhu J, Ju G, Hua X. Hepatitis E virus infection among domestic animals in eastern China. Zoonoses Public Health. 2008;55 (6):291-298.影响因子IF=2.2

13. Zhang W, Shen Q, Hua X, Cui L, Liu J, Yang S. The first Chinese porcine sapovirus strain that contributed to an outbreak of gastroenteritis in piglets. Journal of Virology. 2008; 82(16):8239-40.影响因子IF=5.2

(二)通讯作者论文:

1. Yang S, Wang Y, Li W, Fan Z, Jiang L, Lin Y, Fu X, Shen Q, Sun Z, Wang X, Deng X, Zhang W*, Delwart E. Virus Genes. A novel bocavirus from domestic mink, China. 2016 Dec;52(6):887-890.

2. Wang X, Wang J, Zhou C, Yang S, Shen Q, Zhang W*, Qi D. Viral metagenomics of fecal samples from non-human primates revealed human astrovirus in a chimpanzee, China. Gut Pathog. 2016 Nov 8;8:53.

3. Yang S, Liu Z, Wang Y, Li W, Fu X, Lin Y, Shen Q, Wang X, Wang H, Zhang W*.A novel rodent Chapparvovirus in feces of wild rats. Virol J. 2016 Jul 29;13:133.

4. Liu Z, Yang S, Wang Y, Shen Q, Yang Y, Deng X, Zhang W*, Delwart E. Identification of a novel human papillomavirus by metagenomic analysis of vaginal swab samples from pregnant women. Virol J. 2016 Jul 4;13:122.

5. Wang X, Shao S, Wang H, Shen Q, Yang S, Zhang W*. An enterovirus from a captive primate in China. Springerplus. 2016 Aug 8;5(1):1281

6. Kang YJ, Huang W, Zhao AL, Lai DD, Shao L, Shen YQ, Deng X, Delwart E, Zhang W*.Densoviruses in oyster Crassostrea ariakensis. Arch Virol. 2017 Jul;162(7):2153-2157.

7. Yang S, Liu D, Wang Y, Qu F, He Y, Sun Z, Shen Q, Li W, Fu X, Deng X, Zhang W*, Delwart E. Bufavirus Protoparvovirus in feces of wild rats in China. Virus Genes. 2016 Feb;52(1):130-3.

8. Li W, Gu Y, Shen Q, Yang S, Wang X, Wan Y, Zhang W*. A novel gemycircularvirus from experimental rats. Virus Genes. 2015 Oct;51(2):302-5.

9. Tian H, Fu X, Li W, Huang Y, Sun J, Zhou G, Zhou C, Shen Q, Yang S, Zhang W*. Genotype 4 Hepatitis E Virus Prevalent in Eastern China Shows Diverse Subtypes. Hepat Mon. 2015 Jun 23;15(6):e25367.

10. Zhou C, Tian H, Wang X, Liu W, Yang S, Shen Q, Wang Y, Ni B, Chen S, Fu X, Fei R, Zhang W*.The genome sequence of a novel simian adenovirus in a chimpanzee reveals a close relationship to human adenoviruses.Arch Virol. 2014 Jul;159(7):1765-70.

11. Sun G, Yi M, Tian H, Yang S, Han J, Wang X, Wang Y, Shen Q, Wang H, Shao S, Yan Y, Zhang W*. A novel human enterovirus recombinant from a child with diarrhea. Arch Virol. 2014 Feb;159(2):333-337.

12. Wang X, Zhang X, Tian H, Ling F, Yu M, Sun G, Yang S, Shen Q, Wang Y, Shao S, Zhang W*.Complete genomes of three human bocavirus strains from children with gastroenteritis and respiratory tract illnesses in Jiangsu, China.J Virol. 2012 Dec;86(24):13826-7.

13. Hua Wang, Yilin He, Quan Shen, Xiaochun Wang, Shixing Yang, Li Cui, Liping Ren, Guangming Sun, Xiuguo Hua, Shihe Shao, Wen Zhang*, The complete genome sequence of the genotype 4 hepatitis E virus strain prevalent in swine group in Jiangsu province, China, reveals close relationship with that from human population in this area. J Virol. 2012 Aug;86(15):8334-8335.

14. Wang H, Zhang W*, Ni B, Shen H, Song Y, Wang X, Shao S, Hua X, Cui L. Recombination analysis reveals a double recombination event in hepatitis E virus.Virol J. 2010;7:129.

15. Shen Q, Pu Y, Fu X, Xie Y, Bian X, Yang S, Yang Y, Cui L, Wang X, Wang H, Zhang W*. Changes in the cellular proteins of A549 infected with hepatitis E virus by proteomics analysis. BMC Vet Res. 2014 Aug 30;10(1):188.

16. Qi D, Shan T, Liu Z, Deng X, Zhang Z, Bi W, Owens JR, Feng F, Zheng L, Huang F, Delwart E, Hou R, Zhang W*. A novel polyomavirus from the nasal cavity of a giant panda (Ailuropoda melanoleuca). Virol J. 2017 Oct 27;14(1):207.

 

获奖情况:

1. 2017年,戊型肝炎病毒流行规律及跨种间传播分子机制研究,江苏省科学技术奖三等奖;排名第一;

2. 2017年,病毒感染性疾病的病毒宏基因组学诊断方法的建立及其应用,江苏省卫计委医学新技术引进奖二等奖,排名第三;

3. 2013年,我国华东地区人畜共患戊型肝炎病毒毒株遗传多样性研究,泰州市科学技术奖二等奖;排名第三;

4. 2011年,戊型肝炎病毒病原学及致病机制研究;上海市科技进步奖三等奖,排名第四;

5. 2011年,华东地区戊型肝炎病毒多样性研究,镇江市优秀科技论文一等奖,排名第一。