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张苗苗

江苏大学,医学院,讲师

教育经历:
2008/09至2011/07  南开大学 医学院 免疫学  博士
2005/09至2008/07  四川师范大学 生命科学学院 细胞生物学 硕士
2001/09至2005/07  阜阳师范学院 生物系 学士

工作经历:
2014/09至今 江苏大学医学院 硕士生导师
2014/07至今 江苏大学食品学院 博士后
2011/07至今 江苏大学医学院 讲师

主持或参加科研项目及人才计划项目情况:
1. 国家自然基金青年项目,31200676,miR-30b/d 调控肝基质细胞诱导的调节性树突状细胞功能机制的研究,2014/01-2016/12,25万元,已结题,主持。
2. 教育部博士点青年教师基金,20123227120008、miR-30b/d 调控肝基质细胞诱导的调节性树突状细胞功能机制的研究,2014/01-2015/12,4万元,在研,主持。
3. 中国博士后科学基金面上项目,2015M571705,钆掺杂碳量子点用于影像导航的肝癌放疗增敏作用的研究,2015/01-2017/12,5万元,在研,主持人。
4. 国家自然基金青年项目,81301316,多功能聚胺基碳量子点的制备及其应用于siRNA基因转运和示踪成像的研究,2014/01-2016/12,24万元,在研,参与人(排名第二)。
5. 中国博士后科学基金特别资助项目,2014T70486,MRI-荧光钆掺杂型碳量子点在肝癌早期诊疗中的应用,2014/01-2016/12,15万元,在研,参与人(排名第二)。

发表主要论文:
1.Miaomiao Zhang, Huixiang Ju, Li Zhang, Mingzhong Sun, Zhongwei Zhou, Zhenyu Dai, Lirong Zhang, Aihua Gong, Fengyi Du. Engineering iodine-doped carbon dots as dual-modal probes for fluorescence and X-ray CT imaging. International journal of nanomedicine. 2015 6; 10: 6943-53.
2.Zhang M, Liu Q, Mi S, Liang X, Zhang Z, Su X, Liu J, Chen Y, Wang M, Zhang Y, Guo F, Zhang Z, Yang R. Both miR-17-5p and miR-20a alleviate suppressive potential of myeloid-derived suppressor cells by modulating STAT3 expression. J Immunol. 2011 15; 186 (8): 4716-24.
3.Fengyi Du, Miaomiao Zhang, Xiaofeng Li, Jianan Li, Xinyi Jiang , Zhou Zhou, Jing Yuan, Zhang Li , Hua Ye, Qixiang Shao, Ming Zhou, Aihua Gong. Economical and green synthesis of bagasse-derived fluorescent carbon dots for biomedical applications. Nanotechnology. 2014, 25(31): 315702. (The first co-author).
4.Fengyi Du, Xin Jin, Junhui Chen, Ye Hua, Mulan Cao, Lirong Zhang, Jianan Li, Li Zhang, Jie Jin, Chaoyang Wu, Aihua Gong, Wenrong Xu, Qixiang Shao, Miaomiao Zhang, Nitrogen-doped carbon dots as multifunctional fluorescent probes. Journal of Nanoparticle Research. 2014, 16:2720. 
5.Wang J, Zhuo Y, Yin L, Wang H, Jiang Y, Liu X, Zhang M, Du F, Xia S, Shao Q.  Doxycycline Protects Thymic Epithelial Cells from Mitomycin C-Mediated Apoptosis In Vitro via Trx2-NF-x03BA;B-Bcl-2/Bax Axis. Cell Physiol Biochem. 2016;38(2):449-60.
6.Xia S, Li XP, Cheng L, Han MT, Zhang MM, Shao QX, Xu HX, Qi L. Fish Oil Rich Diet Promotes Hematopoiesis and Alters Hematopoietic Niche. Endocrinology. 2015 Aug;156(8):2821-30.
7.Liang X, Liu Y, Mei S, Zhang M, Xin J, Zhang Y, Yang R. MicroRNA-22 impairs anti-tumor ability of dendritic cells by targeting p38. PLoS One. 2015 Mar 31;10(3):e0121510. 
8.Fengyi Du, Jianan Li, Miaomiao Zhang, Zhou Zhou, Jing Yuan, Jun Wang, Li Zhang, Xia Liu, Genbao Shao, Jie Jin, Sheng Xia, Shiming Yang, Aihua Gong, Wenrong Xu, Qixiang Shao, Multicolor nitrogen-doped carbon dots for live cell imaging. Journal of biomedical nanotechnology. 2015. 11, 780-788. 
9.Fengyi Du, Jing Yuan, Miaomiao Zhang, Jianan Li, Zhou zhou, Zhang Li, Mulan Cao, Wanxin Peng, Junhui Chen, Aihua Gong, Wenrong Xu, Qixiang Shao.Facile Synthesis of Biocompatible Nitrogen-doped Carbon Dots for Bioimaging. RSC advance. 2014, 4 (71), 37536-37541. 
10.Liu X, Zhao Q, Peng X, Xia S, Shen W, Zong Y, Cheng J, Wu W, Zhang M, Du F, Xu W, Qian H, Shao Q. PTD-mediated intracellular delivery of mutant NFAT minimum DNA binding domain inhibited the proliferation of T cells. Int Immunopharmacol. 2014; 19 (1) :110-8
11.Sheng Xia ,Xiaoping Li, Lu Cheng, Mutian Han, Miaomiao Zhang , Xia Liu, Huaxi Xu, Minghui Zhang, Qixiang Shao, Ling Qi. Chronic intake of high fish oil diet induces myeloid‑derived suppressor cells to promote tumor growth. Cancer Immunol Immunother (2014) 63:663–673.
12.Sheng Xia, Mutian Han, Xiaoping Li, Lu Cheng, Yetao Qiang, Shuiyun Wu, Miaomiao Zhang, Huaxi Xu, Xia Liu and Qixiang Shao. Dietary fish oil exacerbates concanavalin A induced hepatitis through promoting hepatocyte apoptosis and altering immune cell populations. J Toxicol Sci. 2014 Apr;39(2):179-90.
13.Min S, Liang X, Zhang M, Zhang Y, Mei S, Liu J, Liu J, Su X, Cao S, Zhong X, Li Y, Sun J, Liu Q, Jiang X, Che Y, Yang R.Multiple tumor-associated microRNAs modulate the survival and longevity of dendritic cells by targeting YWHAZ and Bcl2 signaling pathways. J Immunol. 2013 Mar 1;190(5):2437-46
14.Liu X, Xu X, Lin X, Tian Y, Ji B, Xia S, Xu S, Yin Q, Zhang M, Jiao Z, Wang S, Xu H, Shao Q. PTD-hFOXP3 protein acts as an immune regulator to convert human CD4(+)CD25(-) T cells to regulatory T-like cells. J Cell Biochem. 2012 Dec;113(12):3797-809.
15.Fengyi Du, Wei zhao, Miaomiao Zhang, Hongli Mao, Deling Kong, Jun Yang*, The synergistic effect of aligned nanofiber and hyaluronic acid coating on endothelial cell behavior for vascular tissue engineering, Journal of Nanoscience and Nanotechnology, 2011. 11(8), 6718-6725. 
16.Jing Z, Yuan X, Zhang J, Huang X, Zhang Z, Liu J, Zhang M, Oyang J, Zhang Y, Zhang Z, Yang R. Chromosome 1 open reading frame 190 promotes activation of NF-κB canonical pathway and resistance of dendritic cells to tumor-associated inhibition in vitro. J Immunol. 2010 Dec 1;185(11):6719-27

专利申请: 
1. 发明人: 杜凤移,张苗苗,邵启祥,夏圣,许化溪,许文荣,钱晖,刘霞。 发明名称:一种高荧光性能碳量子点的制备方法。申请号:CN201310168911。
2. 发明人:杜凤移,居会祥,孙明忠,张苗苗,张丽,房正邹,赵雪芬。发明名称:一种荧光-CT双模态影像探针及其制备方法。申请号:CN 201510062498.9。
3. 发明人:杜凤移,张丽,张礼荣,张苗苗,华晔,龚爱华,邵启祥。发明名称:一种基于碳量子点的荧光-MRI双模态影像探针的制备方法及其应用。申请号:CN 201410393976.0。
4. 发明人:张苗苗,杜凤移,龚爱华,邵启祥,邵根宝,彭琬昕,金洁,吴卫疆,周洲,袁婧。发明名称:一种环保经济型荧光碳量子点的制备方法。申请号:CN201310225051。
5. 发明人: 刘乔飞,张苗苗,王萌萌,陈颖莹,张园,杨荣存。发明名称: miR-223的用途。申请号: CN200910244804.5。
6. 发明人: 杨荣存,张园,张苗苗,刘乔飞,陈颖莹,王萌萌。发明名称: 微小RNA的新用途。申请号: CN201010551655.X。