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田洁

江苏大学,医学院,副教授硕士生导师

江苏省“六大人才高峰”高层次人才

江苏大学“优秀青年骨干教师”

主讲课程:

本科:《医学免疫学》,《临床免疫学检验》,《Immunology》(留学生)

研究方向:自身免疫性疾病的机制及治疗;肿瘤免疫

学术兼职:江苏省免疫学会转化医学专业委员会常务委员,江苏省免疫学会青年委员及监事,Member of American Association of Immunologists

主持或参加科研项目及人才计划项目情况(按时间倒序排序):

 1、国家自然科学基金(青年基金),81601424GITRL/GITR信号通过调控MDSCs参与小鼠实验性干燥综合征的机制研究2017/01-2019/1217万元,在研,主持。

 2、江苏省自然科学基金(青年基金),BK20150533,小鼠 ESS 发病过程中 GITRL 对髓源性抑制细胞的调控作用,2015/07-2018/0620.0万元,在研,主持。

 3、中国博士后特别资助项目,2017T100336间充质干细胞通过调控MDSCs抑制ESS的机制研究2017/07-2019/0615万元,在研,主持。

 4、中国博士后科学基金项目,2016M590423GITRL对髓源性抑制细胞的调控的信号通路研究2016/07-2018/068.0万元,在研,主持。

 5、江苏大学高级人才科研启动基金,15JDG070miR-9 对髓源性抑制细胞的分化及功能的调控研究2015/01-2017/125.0万元,在研,主持。

 6、江苏省“六大人才高峰”高层次人才项目,YY-006,间充质干细胞的外泌体治疗原发性干燥综合征的研究,2017/10-2020/093万元,在研,主持。

 7、江苏大学“青年英才培育计划”,2017/06-2020/0510.0万元,主持。

 8、国家自然科学基金面上项目,31470881,髓源性抑制细胞来源的exosomes抑制小鼠胶原诱导性关节炎的实验研究,2015/01-2018/1285.0万元,在研,参加。

 9国家自然科学基金(青年基金),81701612,嗅粘膜来源间充质干细胞的外泌体抑制小鼠实验性干燥综合征的机制研究,2018/01-2020/1220万元,在研,参与。

 10、国家自然科学基金国际合作与交流项目,81310108020GITRL/GITR调控Th17细胞分化的信号通路研究,2013/03-2013/124.0万元,已结题,参加。

 11、国家自然科学基金面上项目,31170849beta-葡聚糖促进髓源性抑制细胞分化作用及其机制研究,2012/01-2015/1260.0万元,已结题,参加。

 12、国家自然科学基金面上项目,81072453GITRL 在小鼠胶原诱导性关节炎发生中的作用及其机制研究,2011/01-2013/1230.0万元,已结题,参加。

发表SCI论文:(#第一作者,*通讯作者)

(1) Tian J#, Rui K#, Tang X, Ma J, Wang Y, Tian X, Zhang Y, Xu H, Lu L, and Wang S*. MicroRNA-9 regulates the differentiation and function of myeloid-derived suppressor cells via targeting Runx1. The Journal of Immunology. 2015; 195(3):1301-1311.

(2) Tian J, Ma J, Ma K, Guo H, Baidoo SE, Zhang Y, Yan J, Lu L, Xu H, and Wang S*. β-Glucan enhances antitumor immune responses by regulating differentiation and function of monocytic myeloid-derived suppressor cells. European Journal of Immunology. 2013; 43(5):1220-1230.

(3) Tian J#, Rui K#, Tang X#, Wang W, Ma J, Tian X, Wang Y, Zhang Y, Xu H*, Lu L*, and Wang S*. IL-17 down-regulates the immunosuppressive capacity of olfactory ecto-mesenchymal stem cells in murine collagen-induced arthritis. Oncotarget. 2016; 7(28) : 42953-42962.

(4)  Tian J, Ma J, Ma K, Ma B, Tang X, Baidoo SE, Tong J, Yan J, Lu L, Xu H, and Wang S*. Up-regulation of GITRL on dendritic cells by WGP improves anti-tumor immunity in murine Lewis lung carcinoma. PLoS ONE. 2012; 7(10):e46936.

(5)  Tian J , Zhang Y, Yang X , Rui K , Tang X , Ma J , Chen J , Xu H , Lu L , and Wang S*. Ficus carica Polysaccharides promote the maturation and function of dendritic cells. International Journal of Molecular Sciences. 2014; 15(7):12469-12479.

(6) Tian J, Rui K, and Wang S*. Roles of miRNAs in regulating the differentiation and maturation of myeloid-derived suppressor cells. Medical Hypotheses. 2014; 83(2):151-153.

(7) Tian J#, Ma J#, Wang S*, Yan J*, Chen J, Tong J, Wu C, Liu Y, Ma B, Mao C, Jiao Z, Shao Q, Lu L, Xu H. Increased expression of mGITRL on D2SC/1 cells by particulate β-glucan impairs the suppressive effect of CD4+CD25+ regulatory T cells and enhances the effector T cell proliferation. Cellular Immunology. 2011; 270(2):183-187.

(8) Tian X#, Tian J#, Tang X, Rui K, Zhang Y, Ma J, Wang Y, Xu H, Lu L, Wang S*. Particulate β-glucan regulates the immunosuppression of granulocytic myeloid-derived suppressor cells by inhibiting NFIA expression. Oncoimmunology. 2015; 4(9):e1038687.

(9) Tian X#, Tian J#, Tang X, Ma J, Wang S*. Long non-coding RNAs in the regulation of myeloid cells. Journal of Hematology & Oncology. 2016; 9(1):99.

(10) Tang X#, Tian J#, Ma J, Wang J, Qi C, Rui K, Wang Y, Xu H, Lu L, and Wang S*. GITRL modulates the activities of p38 MAPK and STAT3 to promote Th17 cell differentiation in autoimmune arthritis. Oncotarget. 2016; 7(8):8590-8600.

(11) Wang Y#, Tian J#, Tang X#, Rui K, Tian X, Ma J, Ma B, Xu H, Lu L, Wang S*. Exosomes released by granulocytic myeloid-derived suppressor cells attenuate DSS-induced colitis in mice. Oncotarget. 2016; 7(13):15356-15368.

(12) Wang J#, Zhang Y#, Yin K#, Xu P, Tian J*, Ma J, Tian X, Wang Y, Tang X, Xu H, Wang S*. IL-17A weakens the antitumor immuity by inhibiting apoptosis of MDSCs in Lewis lung carcinoma bearing mice. Oncotarget. 2017; 8(3):4814-4825.

(13) Peng H#, Liu Y#, Tian J#, Ma J, Tang X, Rui K, Tian X, Mao C, Lu L, Xu H, Jiang P*, Wang S*. The long noncoding RNA IFNG-AS1 promotes T helper type 1 cells response in patients with Hashimoto’s Thyroiditis. Scientific Reports. 2015; 5:17702.

(14) Chen J#, Tian J#, Tang X#, Rui K, Ma J, Mao C, Liu Y, Lu L, Xu H, Wang S*. MiR-346 regulates CD4+CXCR5+ T cells in the pathogenesis of Graves’ disease. Endocrine. 2015; 49(3):752-760.

(15) Rui K#, Tian J#, Tang X, Ma J*, Xu P*, Tian X, Wang Y, Xu H, Lu L, and Wang S*. Curdlan blocks the immune suppression by myeloid-derived suppressor cells and reduces tumor burden. Immunologic Research. 2016; 64(4):931-939.

(16) Chen Y#, Tian J#, Tian X , Tang X, Rui K, Tong J, Lu L, Xu H, Wang S*. Adipose tissue dendritic cells enhances iInflammation by prompting the generation of Th17 Cells. PLoS ONE. 2014; 9(3):e92450.

(17) Liu Y#, Tang X#, Tian J#, Zhu C, Peng H, Rui K, Wang Y, Mao C, Ma J, Lu L, Xu H*, Wang S*. Th17/Treg cells imbalance and GITRL profile in patients with Hashimoto’s Thyroiditis. International Journal of Molecular Sciences. 2014; 15(12):21674-21686.

(18) Zhang Y, Wang J, Wang W, Tian J*, Yin K*, Tang X, Ma J, Xu H, Wang S*. IL-17A produced by peritoneal macrophages promote the accumulation and function of granulocytic myeloid-derived suppressor cells in the development of colitis-associated cancer. Tumour biology. 2016; 37(12):15883-15891.

(19) Tang X#, Yin K#, Zhu H#, Tian J*, Shen D, Yi L, Rui K, Ma J, Xu H, Wang S*. Correlation between the expression of microRNA-301a-3p and the proportion of Th17 cells in patients with rheumatoid arthritis. Inflammation. 2016; 39(2):759-767.

(20) Wang Y, Tian J*, Wang S*. The potential therapeutic role of myeloid-derived suppressor cells in autoimmune arthritis. Seminars in Arthritis and Rheumatism. 2016; 45(4):490-495.

(21) Wang J#, Peng H#, Tian J*#, Ma J, Tang X, Rui K, Tian X, Wang Y, Chen J, Lu L, Xu H,   Wang S*. Upregulation of long noncoding RNA TMEVPG1 enhances T helper type 1 cell response in patients with Sjögren syndrome. Immunologic Research. 2016; 64(2):489-496.

(22) Peng H#, Liu Y#, Tian J*#, Ma J, Tang X, Yang J, Rui K, Zhang Y, Mao C, Lu L, Xu H, Wang S*. Decreased expression of microRNA-125a-3p upregulates interleukin-23 receptor in patients with Hashimoto’s thyroiditis. Immunologic Research. 2015; 62(2):129-136.

  (23) Yuan J#, Tang X#, Yin K#, Tian J*, Rui K, Ma J, Mao C, Chen J, Lu L, Xu H, Wang S*. GITRL as a genetic adjuvant enhances enterovirus 71 VP1 DNA vaccine immunogenicity. Immunologic Research. 2015; 62(1):81-88.

获得荣誉及学术奖励

1. 田洁1/1),β-葡聚糖对髓源性抑制细胞的分子调控及其在抗瘤免疫中的作用,江苏省学位委员会,江苏省优秀博士论文,2015

2. 田洁 7/7),GITRL调控机体Treg/Th17细胞增强抗肿瘤免疫应答的研究,江苏省人民政府,江苏省科学技术奖,三等奖,2012

3. 田洁 3/5),自身免疫性甲状腺疾病患者新型CD4+辅助性T细胞亚群检测及临床意义,江苏省医学会,江苏医学科技奖,三等奖,2014

4. 田洁4/5),Th17细胞调控类风湿性关节炎发病的机制研究,江苏省医学会,江苏医学科技奖,三等奖,2016

5. 田洁1/1),医学免疫与临床应用高峰论坛—“青年学者论坛”,中国工程院医药卫生学部,二等奖,2017