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杨鲲

 

医学博士,教授,博士生导师

地址江苏省镇江市学府路301号 江苏大学医学院解剖学教研室邮编212013

电话:0511-8595 9086

邮箱:yangk@ujs.edu.cn

学历

1988-1994 中国人民解放军第四军医大学本科生(六年制)

1995-1997 第四军医大学硕士研究生(人体解剖与组织胚胎学)

1999-2003 第四军医大学博士研究生(人体解剖与组织胚胎学)

职历

1997-1999 日本佐贺医科大学生理学系,外国人研究员

1999-2001 第四军医大学解剖学教研室讲师

2001-2002 日本九州大学医学部生理学系,外国人研究员

2002-2003 佐贺医科大学文部科学省教官

2005-2013 美国马里兰大学博士后、Research Associate

2014-        江苏大学医学院

研究

神经生物学,疼痛治疗的转化医学

运用神经电生理学神经解剖学行为学方法,结合笼锁递质光遗传学方法及全息亚细胞水平记录等,围绕疼痛传递和调控的机制,探讨疼痛治疗的新策略。

获奖

(1) 全国优秀博士学位论文(教育部,2005

(2) 中华医学奖(一等奖,排名第二)(中华医学会,2004

(3) 全军优秀博士学位论文(解放军总参谋部,2004

近年论文

[1] Chen Q, Shao C, Zhou H, Ma R, Jiang P, *Yang K. Differential sensitivity of pre- and postsynaptic GABAB receptors in rat periaqueductal gray. NeuroReport, 2017, 28:1221-1224 (*, corresponding author).

[2] Li G, Shao C, Chen Q, Wang Q, *Yang K. Accumulated GABA activates presynaptic GABAB receptors and inhibits both excitatory and inhibitory synaptic transmission in rat midbrain periaqueductal gray. NeuroReport, 2017, 28:313-318 (*, corresponding author).

[3] *Yang K. Regulation of excitability in tonic firing substantia gelatinosa neurons of the spinal cord by small-conductance Ca2+-activated K+ channels. Neuropharmacology, 2016, 105:15-24 (*, corresponding author).

[4] *Yang K. Postnatal excitability development and innervation by functional transient receptor potential vanilloid 1 (TRPV1) terminals in neurons of the rat spinal sacral dorsal commissural nucleus: an electrophysiological study. Molecular Neurobiology, 2016, 53:6033-6042 (*, corresponding author).

[5] Li G, Liu Z-L, Zhang W-N, *Yang K. Blockade of presynaptic 4-aminopyridine-sensitive potassium channels increases initial neurotransmitter release probability, reinstates synaptic transmission altered by GABAB receptor activation in rat midbrain periaqueductal gray. NeuroReport, 2016, 27:50-55 (*, corresponding author).

[6] *Yang K, Ma R, Wang Q, Jiang P, Li Y-Q. Optoactivation of parvalbumin neurons in the spinal dorsal horn evokes GABA release that is regulated by presynaptic GABAB receptors. Neuroscience Letters, 2015, 594:55-59 (*, corresponding author).

[7] Nagode DA, Tang A-H, Yang K, Alger BE. Optogenetic identification of an intrinsic cholinergically-driven inhibitory oscillator sensitive to cannabinoids and opioids in hippocampal CA1. Journal of Physiology (London), 2014, 592:103-123.

[8] Liu J, Ren Y, Li G, Liu Z-L, Liu R, Tong Y, Zhang L, *Yang K. GABAB receptors resist acute desensitization in both postsynaptic and presynaptic compartments of periaqueductal gray neurons. Neuroscience Letters, 2013, 543:146-151 (*, corresponding author).

[9] Liu Z-L, Ma H, Xu R-X, Dai Y-W, Zhang H-T, Yao X-Q, *Yang K. Potassium channels underlie postsynaptic but not presynaptic GABAB receptor-mediated inhibition on ventrolateral periaqueductal gray neurons. Brain Research Bulletin, 2012, 88:529-533 (*, corresponding author).

[10] *Yang K, Ma H. Blockade of GABAB receptors facilitates evoked neurotransmitter release at spinal dorsal horn synapse. Neuroscience, 2011, 193:411-420 (*, corresponding author).

[11] #Yang K, #Takeuchi K, Wei F, Dubner R, Ren K. Activation of group I mGlu receptors contributes to facilitation of NMDA receptor membrane current in spinal dorsal horn neurons after hind paw inflammation in rats. European Journal of Pharmacology, 2011, 670:509-518 (#, co-first author).

[12] Dinocourt C, Aungst S, Yang K, Thompson SM. Homeostatic increase in excitability in area CA1 after Schaffer collateral transection in vivo. Epilepsia, 2011, 52:1656-1665.