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夏圣

联系方式:

Email:xiasheng1519@163.com

江苏大学医学院,

江苏省镇江市学府路301号江苏大学医学楼, 邮编  212013


个人简介:

教授,医学博士,美国康奈尔大学博士后。现任江苏大学医学院医学检验系副主任,免疫学与免疫检验学教研室主任,江苏省免疫学会理事。在BloodJBCEndocrinologyCancer Immunology & ImmunotherapyDiabetesJ Immunol、中国免疫学杂志、临床检验杂志等国内外期刊上发表研究论文,主编及参与编著教材、专著近十部,主持省精品课程一门。


主讲课程:

《医学免疫学》(本科)、《临床免疫检验学》(本科)、《医学免疫学技术》(硕士研究生)、《Immunology(MBBS留学生)、《免疫学进展》(博士研究生)、《Advance in Immunology(留学研究生)等。


科研方向:

树突状细胞与免疫调节、代谢免疫、细胞免疫治疗、免疫诊断试剂研发等。


近五年主持的主要科研项目:

1.高脂肥胖对肠道区域树突状细胞的影响及相关机制研究 (31570879),国家自然科学基金面上项目,(主持)

2.肥胖通过调控肠道菌群影响调节性T细胞功能的研究  31428006),国家自然科学基金海外及港澳学者合作研究项目,  (国内主持人)

3.ω-3 脂肪酸诱导免疫耐受、促造血干细胞分化机制及其应用研究(81172834),国家自然科学基金面上项目,(主持)


近期发表的主要论文:

1.XiaS*, Li XP, Cheng L, Han MT, Zhang MM, Shao QX, Xu HX, Qi L. Fish Oil-Rich DietPromotes Hematopoiesis and Alters Hematopoietic Niche. Endocrinology.2015;156(8):2821-30.  (通讯作者)

2.ChenD, Wang Y, Wang H, Wu Y, Xia S*, Zhang M. CD8(+) T activation attenuates CD4(+)T proliferation through dendritic cells modification. Cell Immunol.2015;296(2):138-48. (通讯作者)

3.LiuX, Ji B, Sun M, Wu W, Huang L, Sun A, Zong Y, Xia S, Shi L, Qian H, Xu W, ShaoQ. Cell-penetrable mouse forkhead box protein 3 alleviates experimentalarthritis in mice by up-regulating regulatory T cells. Clin Exp Immunol.2015;181(1):87-99.

4.LiY, Ji X, Su Z, Tong J, Xia S, Chen X, Lu P, Barnie PA, Wang S, Huang X, Xu H.Downregulation of Runx3 is closely related to the decreased Th1-associatedfactors in patients with gastric carcinoma.Tumour Biol. 2014;35(12):12235-44..

5.LiuX, Zhao Q, Peng X, Xia S, Shen W, Zong Y, Cheng J, Wu W, Zhang M, Du F, Xu W,Qian H, Shao Q. PTD-mediated intracellular delivery of mutant NFAT minimum DNAbinding domain inhibited the proliferation of T cells. Int Immunopharmacol.2014;19(1):110-8

6.XiaS*, Li X, Cheng L, Han M, Zhang M, Liu X, Xu H, Zhang M, Shao Q, Qi L. Chronicintake of high fish oil diet induces myeloid-derived suppressor cells topromote tumor growth. Cancer Immunol Immunother. 2014;63(7):663-73.  (通讯作者)

7.XiaS*, Han M, Li X, Cheng L, Qiang Y, Wu S, Zhang M, Xu H, Liu X, Shao Q. Dietaryfish oil exacerbates concanavalin A induced hepatitis through promotinghepatocyte apoptosis and altering immune cell populations. J Toxicol Sci.2014;39(2):179-90.  (通讯作者)

8.ShaH, Yang L, Liu M, Xia S, Liu Y, Liu F, Kersten S, Qi L. Adipocyte spliced formof X-box-binding protein 1 promotes adiponectin multimerization and systemicglucose homeostasis. Diabetes. 2014;63(3):867-79.

9.GuY, Yang P, Shao Q, Liu X, Xia S, Zhang M, Xu H, Shao Q. Investigation of theexpression patterns and correlation of DNA methyltransferases and class Ihistone deacetylases in ovarian cancer tissues. Oncol Lett. 2013;5(2):452-458.

10.TongJ, Han Q, Wang S, Su Z, Zheng D, Shen P, Xia S, Huang X, Shao Q, Xu H.Corynebacterium pyruviciproducens, as an immune modulator, can promote theactivity of macrophages and up-regulate antibody response to particulateantigen. Exp Biol Med (Maywood).2012;237(11):1322-30.

11.SunS, Xia S, Ji Y, Kersten S, Qi L. The ATP-P2X7 signaling axis is dispensable forobesity-associated inflammasome activation in adipose tissue. Diabetes.2012;61(6):1471-8.

12.XuX, Yi H, Guo Z, Qian C, Xia S, Yao Y, Cao X. Splenic stroma-educated regulatorydendritic cells induce apoptosis of activated CD4 T cells via FasL-enhancedIFN-[gamma] and nitric oxide. J Immunology. 2012 188 (3): (3):1168-77

13.LiuX, Xu X, Lin X, Tian Y, Ji B, Xia S, Xu S, Yin Q, Zhang M, Jiao Z, Wang S, XuH, Shao Q. PTD-hFOXP3 protein acts as an immune regulator to convert humanCD4(+)CD25(-) T cells to regulatory T-like cells. J Cell Biochem.2012;113(12):3797-809.

14.JiY, Sun S, Xia S, Yang L, Li X, Qi L. Short term high fat diet challengepromotes alternative macrophage polarization in adipose tissue via naturalkiller T cells and interleukin-4. J Biol Chem. 2012;287(29):24378-86

15.QingzhenH, Jia T, Shengjun W, Yang Z, Yanfang L, Pei S, Essien BS, Zhaoliang S, ShengX, Qixiang S, Finegold SM, Xu H. Corynebacterium pyruviciproducens promotes theproduction of ovalbumin specific antibody via stimulating dendritic celldifferentiation and up-regulating Th2 biased immune response. Vaccine.2012;30(6):1115-23

16.HeZ, Shotorbani SS, Jiao Z, Su Z, Tong J, Liu Y, Shen P, Ma J, Gao J, Wang T, XiaS, Shao Q, Wang S, Xu H. HMGB1 promotes the differentiation of Th17 viaup-regulating TLR2 and IL-23 of CD14+ monocytes from patients with rheumatoidarthritis. Scand J Immunol. 2012 Nov;76(5):483-90.

17.XiaS*, Sha H, Yang L, Ji Y, Ostrand-Rosenberg S, Qi L. Gr-1+CD11b+ myeloid-derivedsuppressor cells suppress inflammation and promote insulin sensitivity inobesity. Journal of Biological chemistry. 2011, 286: (26):23591-9. (通讯作者)

18.ChenX, Xia S, Li R, Liu H, Huang Y, Qian X, Xiao X, Xu X, Lin X, Tian Y, Zong Y, HeD, Chen W, Zhang Y, Shao Q. Doxycycline enhances the Ras-MAPK signaling andproliferation of mouse thymic epithelial cells. Journal of CellularBiochemistry, 2009, 107: 494-503

19.XiaS, Guo Z, Xu X, Yi H, Wang Q, Cao X. Hepatic microenvironment programs hematopoieticprogenitor differentiation into regulatory dendritic cells, maintaining livertolerance. Blood, 2008, 112: 3175-3185

20.LiQ, Guo Z, Xu X, Xia S, Cao X. Pulmonary stromal cells induce the generation ofregulatory DC attenuating T-cell-mediated lung inflammation. European Journalof Immunology. 2008, 38: 2751-2761

21.XiaS, Guo Z, Yao Y, Xu X, Yi H, Xia D, Cao X. Liver stroma enhances activation ofTLR3-triggered NK cells through fibronectin. Molecular Immunology, 2008, 45:2831-2838